15 research outputs found

    Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer

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    Background: Impairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (<50 years) is rising, there is little data on functional outcomes in this group. Methods: The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, <50 years of age at time of diagnosis and with documented follow-up including functional outcomes. Results: A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%). Conclusion: A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters

    Histories in Stone: The Musin Rebellion Stelae and Contested Factional Histories

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    The 1728 Musin Rebellion was a failed attempt by factional members to overthrow militarily King Yŏngjo’s government. Between 1736 and 1837, six stelae, dedicated to loyal subjects who resisted the rebels, were erected in three different provinces. These stelae contain historical descriptions of the rebellion, its suppression, and the political aftermath. Previous research centred on one stele, represented as evidence of worsening discrimination against Kyŏngsang province elites. This article considers the six stelae in relation to the wider political context of 1728–1837 and analyses consistencies in the text, political connections, location, and the target audience. The stelae reveal complex political struggles in post-rebellion Chosŏn, including a struggle for court recognition by loyalists in areas of rebel strength. Most significantly, the stelae reveal a struggle amongst the victors of the rebellion. The authors attempted to set the record straight over the loyalty of their officials – especially those who had been involved in some form of controversy during the Musin Rebellion – thereby proving their loyalty to Yŏngjo and their right to administer government. To show they were trustworthy court officials, moderate Disciple’s faction supporters were also distancing themselves from Disciple’s faction extremists that had led the Musin Rebellion

    Microsatellite instability in young patients with rectal cancer: Molecular findings and treatment response

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