Effect of adiponectin on reduction of androstenedione serum levels (24h).

<p>Mice previously synchronized with equine gonadotropin chorionic (eCG), were submitted to one of the four different treatments: 1) Group 1- control (PBS), Group 2—adiponectin 0.1 μg/mL, Group 3—adiponectin 1 μg/mL, and Group 4—adiponectin 5 μg/mL. After 24 h the animals were euthanized and serum levels of androstenedione evaluated (mean ± SEM). There was a statistically significant reduction in adiponectin treated groups (ANOVA p = 0.01).</p

Effects of the different doses of adiponectin on markers of direct oxidative stress (AOPP)(A) and anti-oxidant capacity (FRAP and Nox)(B and C).

<p>(A)Compared to control cells, adiponectin treatment (in all doses tested) decreased the AOPP levels (ANOVA, P = 0.0003). (B and C) No differences were seen in terms of anti-oxidant capacity markers, namely FRAP and NoX. Data shown represents mean ± SEM (A) or median (IQ 25–75%) (B and C).</p