Sertraline Treatment of Mood Disorder Associated With Prednisone: A Case Report

The use of corticosteroids, particularly high-potency steroids, for the treatment of various inflammatory conditions has been frequently associated with mood disturbance and psychosis. We report on a 12-year-old white boy treated with high doses of prednisone chronically for 7 years who presented with severe depression, irritability, violence, and psychosis. Sertraline was used to treat depressive as well as psychotic symptoms without the use of antipsychotics. This successful treatment of steroid-induced mood disorder and psychosis with a serotonin reuptake inhibitor is consistent with the literature describing a decrease in central and peripheral serotonin secretion due to steroids, as well as a possible relationship between mood and psychotic symptoms and low cerebrospinal fluid serotonin levels

Cultural Considerations in Child and Adolescent Psychiatric Emergencies and Crises

The United States is a country of immigrants. With the exception of Native Americans, every other American is, or descends from, an immigrant. First- and second-generation immigrant children are the most rapidly growing segment of the American population. The future of American society is ultimately related to the adaptation of these children. Addressing psychiatric emergencies in these populations requires attention to their cultural differences and needs