Age adjusted biopsy criteria.

<p>Age adjusted biopsy criteria.</p

Logistic regression for predicting PCa aggressiveness.

<p>Statistics: Logistic regression (AUC), PSA (ng/ml), PSA density (ng/ml).</p><p>Logistic regression for predicting PCa aggressiveness.</p

Follow up of biopsy-undergraded patients treated with radical prostatectomy, n = 81, 7 patients´ follow up missing→ n = 73, 100%.

<p>Follow up of biopsy-undergraded patients treated with radical prostatectomy, n = 81, 7 patients´ follow up missing→ n = 73, 100%.</p

Logistic regression for predicting PCa aggressiveness sub-analyzed 10 versus 15 biopsy cores; PSA (ng/ml), PSA density (ng/ml), Statistics: Logistic regression (AUC).

<p>Logistic regression for predicting PCa aggressiveness sub-analyzed 10 versus 15 biopsy cores; PSA (ng/ml), PSA density (ng/ml), Statistics: Logistic regression (AUC).</p

Multivariate model; PSA levels (ng/ml) the number of positive biopsy cores and PSA density (ng/ml) for predicting worse final pathological findings; Statistics: *Chi-Quadrat Pearson; **Fisher test.

<p>Multivariate model; PSA levels (ng/ml) the number of positive biopsy cores and PSA density (ng/ml) for predicting worse final pathological findings; Statistics: *Chi-Quadrat Pearson; **Fisher test.</p

Overview about clinical studies on biomarkers predicting undergrading; + positive association,—negative association.

<p>Overview about clinical studies on biomarkers predicting undergrading; + positive association,—negative association.</p

Final GS grade and pathological tumor stage of RPE specimen Statistics: descriptive.

<p>Final GS grade and pathological tumor stage of RPE specimen Statistics: descriptive.</p

Multivariate model.

<p>PSA levels (ng/ml) the number of positive biopsy cores and PSA density (ng/ml) for predicting worse final pathological findings in the population of 10 biopsy cores, Statistics: Chi-Quadrat Pearson test.</p><p>Multivariate model.</p

Patient characteristics, Statistics: descriptive.

<p>Patient characteristics, Statistics: descriptive.</p

Final GS grade and pathological tumor stage of RPE specimen sub-analyzed according to biopsy cores (10 cores versus 15 cores), Statistics: descriptive.

<p>Final GS grade and pathological tumor stage of RPE specimen sub-analyzed according to biopsy cores (10 cores versus 15 cores), Statistics: descriptive.</p