Additional file 2 of Ancestry-driven metabolite variation provides insights into disease states in admixed populations

Additional file 2: Fig. S1. Global ancestry proportions of African, European, and Native American ancestries for participants based on their country of origin: Mainland (Mexico, Central and South America) or Caribbean (Cuba, Dominican Republic, and Puerto Rico). Note that participants from Mainland had a higher proportion of Native American ancestry, while those from Caribbean had a higher proportion of African ancestry. Fig. S2. Volcano plots showing relationship between the direction of association and driving ancestry in the three chromosomes with the largest numbers of associated metabolites. The driving ancestry was the ancestry with the smallest p-value in ancestry-specific testing. In chromosome 2, most of the associations with African ancestry were positive. In chromosome 11, most of the associations with Native American ancestry were negative

Additional file 1 of Ancestry-driven metabolite variation provides insights into disease states in admixed populations

Additional file 1: Table S1. Descriptive statistics of 3,887 HCHS / SOL participants at visit 1. Table S2. Significant metabolites from admixture mapping. Table S3. All-ancestries and ancestry-specific admixture mapping results. Table S4. Regions whose significance was explained by adding all COJO SNVs to model

Additional file 3 of Ancestry-driven metabolite variation provides insights into disease states in admixed populations

Additional file 3: Extended Data Table S1. Significant independent local ancestry regions from admixture mapping. Extended Data Table S2. Genetic variants that do not explain association between local ancestry regions and metabolites. Extended Data Table S3. Replication of significant independent local ancestry regions from admixture mapping for 64 metabolites avaialble in the replication dataset

Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).

<p>Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).</p

Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2.

<p>Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2.</p

Novel SNVs/Genes associated with BP traits in European ancestry.

<p>Novel SNVs/Genes associated with BP traits in European ancestry.</p

Potential novel SNVs/Genes associated with BP traits in African ancestry.

<p>Potential novel SNVs/Genes associated with BP traits in African ancestry.</p

Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1.

<p>Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1.</p

Novel SNVs/Genes associated with BP traits in European ancestry.

<p>Novel SNVs/Genes associated with BP traits in European ancestry.</p