Experimental progress of blood pressure and blood glucose in diabetic eNOS knockout mice treated with riociguat (3 mg/kg/d), telmisartan (1 mg/kg/d), both (3 mg/kg/d and 1 mg/kg/d) or vehicle.

<p>Values are given as means ± SEM. For comparisons, student's t test was used.</p>*<p>p<0.05 vs. diabetic vehicle.</p><p>Additionally non-diabetic eNOS knockout mice treated with vehicle were examined.</p

Venn diagram for the co-occurrences of infectious diseases, malnutrition and cardio-metabolic risk factors in 188 adolescents in rural Ghana.

<p>Data are presented as proportions of the total study population. Infectious diseases comprise malarial infection <i>plus</i> diagnoses of and symptoms compatible with another infectious disease; malnutrition comprises underweight, stunting, iron deficiency and vitamin A deficiency; cardio-metabolic risk factors comprise overweight, obesity, impaired fasting glucose and hypertension.</p

Significant reduction of MDA- positive renal tissue by combination therapy: Immunhistochemical detection of MDA in non-diabetic (A) and diabetic (B) untreated eNOS knockout mice.

<p>Percent volume of MDA-positive area in renal cortex (F). Values are given as means ± SEM. For comparisons, student's t test was used. ^** p<0.01; ^***p<0.001 vs. diabetic vehicle and ^#p<0.05; ^##p<0.01 vs. non-diabetic vehicle. Abbreviations used: <b>MDA</b>, malondialdehyde.</p

Proportions of infectious diseases, malnutrition and cardio-metabolic risk factors in 188 adolescents in rural Ghana.

<p>Error bars indicate 95% confidence intervals. dark grey = infectious diseases, comprise malarial infection <i>plus</i> diagnoses of and symptoms compatible with another infectious disease; light grey = malnutrition, comprises underweight, stunting, iron deficiency and vitamin A deficiency; white = cardio-metabolic risk factors, comprise overweight, obesity, impaired fasting glucose and hypertension.</p

Socio-demographic characteristics of 188 rural Ghanaian adolescents.

<p>Socio-demographic characteristics of 188 rural Ghanaian adolescents.</p

Final urinary albumin as well as organ weights and histology of diabetic mice after 11 weeks of treatment with riociguat (3 mg/kg/d), telmisartan (1 mg/kg/d), riociguat and telmisartan (3 mg/kg/d and 1 mg/kg/d) or vehicle and of non-diabetic control mice, respectively.

<p>Values are given as means ± SEM. For comparisons, student's t test and Mann-Whitney u test, respectively, were used, what appropriate.</p>*<p>p<0.05 vs. diabetic vehicle.</p

Clinical and anthropometric characteristics of 188 rural Ghanaian adolescents.

<p>Clinical and anthropometric characteristics of 188 rural Ghanaian adolescents.</p

Associations of demographic, socio-economic and medical factors with infectious diseases, malnutrition and CRFs.

<p>Associations of demographic, socio-economic and medical factors with infectious diseases, malnutrition and CRFs.</p