Hemoglobin and granulocyte count in infants at birth, one month and three months of age.

<p>A. At birth, group 1-infants with prenatal AZT exposure presented with significantly lower median hemoglobin (13.2 g/dl vs. 15.2 g/dl, p<0.001) than group 2-infants. At one month and at three months of age, differences in median hemoglobin between both groups were no longer significant. B. The median granulocyte count at birth was significantly lower in infants with AZT exposure during pregnancy (5.1/nl in group 1 vs. 7.3/nl in group 2, p<0.05). At one month of age, the median granulocyte count was significantly lower in group 2-infants compared to group 1-infants (3.2/nl in group 1 vs. 1.7/nl in group 2, p = 0.001). No statistically significant differences in granulocyte count were observed at three months of age.</p

Hematological parameters of infants by group at birth, 4–6 weeks of age and 12 weeks of age.

a<p>Mann-Whitney-U-test, all other compared by t-test.</p

Baseline characteristics of infants of group 1 and 2.

a<p>Mann-Whitney-U-test.</p>b<p>Fisher’s exact test; all other compared by t-test.</p

Baseline characteristics of mothers of group 1 and 2.

a<p>Excluded from below socio-demographic comparison.</p>b<p>Mann-Whitney-U-test; all other compared by t-test.</p

Flow chart of study cohort.

<p>Study population and applied statistical tests during antenatal care visits, delivery and follow-up visits at one month and three months post-delivery.</p

Distribution of drug-resistant HIV-1 variants after complex antiretroviral prophylaxis in 50 Tanzanian women.

<p>Distribution of drug-resistant HIV-1 variants after complex antiretroviral prophylaxis in 50 Tanzanian women.</p

Oligonucleotide sequences of primers used in outer and allele-specific PCR (ASPCR).

<p>Oligonucleotide sequences of primers used in outer and allele-specific PCR (ASPCR).</p

Drug-resistant HIV-1 variants in plasma samples of seven children HIV-1 infected by vertical transmission as analyzed by allele-specific PCR (ASPCR).

<p>wt = wild-type HIV-1.</p><p>n/a = not amplifiable.</p><p>- = no sample.</p><p># = sample collected at day 3.</p><p>* = also detected by population-based sequencing.</p><p>° = not detected by population-based sequencing.</p

Box/whisker plots of mitochondrial DNA levels in AZT-exposed and AZT-unexposed placenta and umbilical cords.

<p>Box and whisker plots show mitochondrial DNA (mtDNA) levels in placentas of HIV-1 infected women and in umbilical cords of their infants according to exposure to antenatal AZT. The median mtDNA level was significantly higher in women exposed to AZT compared to women without AZT-exposure. Accordingly, the median mtDNA level was significantly higher in umbilical cords of infants exposed to AZT compared to infants without AZT-exposure.</p

Demographic and clinical characteristics of HIV-1 infected women and their infants with or without AZT exposure during pregnancy.

<p>Demographic and clinical characteristics of HIV-1 infected women and their infants with or without AZT exposure during pregnancy.</p