Comparison of pulmonary vascular permeability index PVPI and global ejection fraction GEF derived from jugular and femoral indicator injection using the PiCCO-2 device: A prospective observational study - Fig 1

<p><b>1A-1F:</b> Bland Altman plots comparing (1A) pulmonary vascular permeability index PVPI_fem_uncor derived from femoral injection without activating of a potential correction by the device to the gold standard measurement PVPI_jug using a jugular CVC for indicator injection, <b>(1B)</b> pulmonary vascular permeability index PVPI_fem_cor derived from femoral injection after activiation of a potential correction by the device to the gold standard measurement PVPI_jug using a jugular CVC for indicator injection, <b>(1C)</b> pulmonary vascular permeability index PVPI derived from femoral indicator injection with (PVPI_fem_cor) and without (PVPI_fem_uncor) activation of a potential correction by the device, <b>(1D)</b> pulmonary vascular permeability index PVPI derived jugular indicator injection PVPI_jug to PVPI-fem_uncor_form which was derived from femoral indicator injection without activation of a potential correction by the device, but correction based on the formula suggested for correction of femoral indicator injection derived GEDVI: GEDVI_corrected [mL / m²] = 0.539 * GEDVI_uncorrected—15.17 + 24.49 * CI_uncorrected 2.311* BW_ideal. PVPI_fem_uncor_form was calculated by multiplying PVPI_fem_uncor with the ratio 0.25*GEDV_uncorrected/0.25*GEDV_corrected, <b>(1E)</b> global ejection fraction GEF_fem_uncor derived from femoral injection without activating of a potential correction by the device to the gold standard measurement GEF_jug using a jugular CVC for indicator injection, <b>(1F)</b> global ejection fraction GEF_fem_cor derived from femoral injection after activiation of a potential correction by the device to the gold standard measurement GEF_jug using a jugular CVC for indicator injection, <b>(1G)</b> global ejection fraction GEF derived from femoral indicator injection with (GEF_fem_cor) and without (GEF_fem_uncor) activation of a potential correction by the device.</p

Ratios and formulas derived from (transpulmonary) thermodilution and pulse contour analysis.

<p>Ratios and formulas derived from (transpulmonary) thermodilution and pulse contour analysis.</p

Algorithm for the calculation of GEDV, GEDVI, PBV, PVPI and GEF as displayed by the PiCCO-2 software V 3.1.

<p>Confounders (volume of VCI) and confounded values with marked deviation from corresponding measurements using jugular access (PBV, PVPI_fem) are shaded. The primarily measured GEDVfem_uncor is indexed to predicted body surface area (BSA) resulting in GEDVI_fem_uncor. In a next step GEDVI_fem_cor is derived from correction of GEDVI_fem_uncor according to the previously suggested formula. Unindexed GEDV_fem_cor results from multiplication of GEDVI_fem_cor by predicted BSA and is used for calculation of GEF_fem_cor. By contrast, PVPI_fem is based on GEDV_fem_uncor irrespective of giving the information about the femoral CVC-position.</p> <p>GEDV(I): global end-diastolic volume (index)</p> <p>PBV: pulmonary blood volume</p> <p>PVPI: pulmonary vascular permeability index</p> <p>GEF: global ejection fraction</p> <p>BSA: body surface area</p

Algorithm assumed for the calculation of GEDV, GEDVI, PBV, PVPI and GEF as displayed by the EV-1000 [5].

<p>Confounders (volume of VCI) and confounded values with marked deviation deviation from corresponding measurements using jugular access (PBV, PVPI_fem) are shaded. The EV-1000 does not correct any parameter derived from femoral CVC indicator injection.</p> <p>GEDV(I): global end-diastolic volume (index)</p> <p>PBV: pulmonary blood volume</p> <p>PVPI: pulmonary vascular permeability index</p> <p>GEF: global ejection fraction</p

Measurements of pulmonary permeability index PVPI_fem_uncor and PVPI_jug categorized “PVPI ≥3”, “1

<p>Measurements classified in the same category are depicted in bold letters.</p