Study variables assessed at high altitude in baseline condition, after 15 minutes of slow breathing exercise and after 5 and 30 minutes of recovery.

<p>Data are separately shown for Study A and B.</p>*<p>-p<0.05, **-p<0.01, ***, p<0.001 vs. baseline; † - p<0.05, †† - p<0.01, †††, p<0.001 vs. slow breathing.</p><p>Sp_O2, blood oxygen saturation; p_tO2– transcutaneous oxygen partial pressure; pt_CO2– transcutaneous CO₂ partial pressure; Et_CO2– end tidal CO₂ pressure in the exhaled air; SBP – systolic blood pressure; DBP – diastolic blood pressure; PP – pulse pressure; HR – heart rate; sPAP – systolic pulmonary artery pressure; RF – respiratory frequency; Vt – tidal volume; VE – minute ventilation; VA – alveolar volume; Dl_CO - pulmonary CO diffusion; TFC – thoracic fluid content.</p

Schematic representation of the sequence of data collection in studies A and B.

<p>Sp_O2, blood oxygen saturation; Pt_O2, transcutaneous oxygen partial pressure; Pt_CO2, transcutaneous CO₂ partial pressure; HR, heart rate; BP, blood pressure; RF, respiratory frequency; PAP, pulmonary artery pressure; Vt, tidal volume; VE, minute ventilation; Dl_CO, pulmonary CO diffusion; VA = alveolar volume; TFC, thoracic fluid content; Pet_CO2, end tidal CO₂ pressure in the exhaled air.</p