7 research outputs found
Increased Incidence of Fractures in Recipients of Hematopoietic Stem-Cell Transplantation
Efficacy of selective screening in identifying patients with hepatitis B before cancer therapy.
Predictors of positive test results in patients with cancer undergoing hepatitis B screening before chemotherapy.
Predictors of positive test results in patients with cancer undergoing hepatitis B screening before chemotherapy.
HIV Testing in Patients With Cancer at the Initiation of Therapy at a Large US Comprehensive Cancer Center
The use of PLDLA/PCL-T scaffold to repair osteochondral defects in vivo
The physiological repair of osteochondral lesions requires the development of a scaffold that is compatible with the structure of the damaged tissue, cartilage and bone. The aim of this study was to evaluate the biological performance of a PLDLA/PCL-T (90/10) scaffold for repairing osteochondral defects in rabbits. Polymeric scaffolds containing saccharose (75% w/v) were obtained by solvent casting and then implanted in the medial knee condyles of 12 New Zealand rabbits after osteochondral damage with a trephine metallic drill (diameter: 3.3 mm) in both medial femoral condyles. Each rabbit received the same treatment, i.e., the polymeric scaffold was implanted on the right side while no material was implanted on the left side (control). Four and 12 weeks later histological examination revealed bone neoformation in the implant group, with the presence of hyaline cartilage and mesenchymal tissue. In contrast, the control group showed bone neoformation with necrosis, exacerbated superficial fibrosis, inflammation and cracks in the neoformed tissue. These findings indicate that the PLDLA/PCL-T scaffold was biocompatible and protected the condyles by stabilizing the lesion and allowing subchondral bone tissue and hyaline cartilage formation