7 research outputs found
Plasma levels of HDL particle subpopulations.
<p>Total lipoprotein mass was calculated as the sum of the mass of total protein, CE, FC, PL and TG for each HDL subpopulation isolated from CETP-deficient subjects (n = 9) and from family control subjects (n = 9).</p
Biological and clinical characteristics of subjects.
***<p>p<0.001, *p<0.05 vs controls. Numbers in parentheses denote % differences vs. controls.</p
Antioxidative activity of HDL particles from CETP-deficient (n = 9) and family control (n = 9) subjects.
<p>Reference LDL (10 mg TC/dl) was incubated at 37°C in PBS in the presence of AAPH (1 mmol/l). Small, dense HDL3b (A), HDL3c (B) or total HDL (C) particles were added to LDL directly before oxidation at 10 mg total mass/dl (A, B) or 40 mg total mass/dl (C). Accumulation of conjugated dienes was continuously measured as the increment in absorbance at 234 nm; two characteristic phases were identified, the lag phase and the propagation phase. To characterise the oxidation kinetics, oxidation rate within the propagation phase and duration of this phase were calculated for each absorbance curve.</p
Characteristics of female ATP-binding cassette transporter 1 <i>(ABCA1</i>) and Lecithin-cholesterol acyltransferase (<i>LCAT</i>) mutation carriers and matched female controls.
<p>Values are means ± SD unless otherwise indicated. Triglycerides are median with interquartile range. P for Student’s T-test. Triglycerides were logtransformed prior to T-test.</p>#<p>P for χ<sup>2</sup> test. No t-test was performed for history of coronary artery disease since referral bias was present. Partial overlap exists between the two control cohorts.</p
24-hour urinary steroid excretion in male <i>ABCA1</i> and <i>LCAT</i> mutation carriers compared to age-matched female controls.
<p>Data are presented as mean ± SD. P values for student’s t-test.</p
Urinary steroid metabolites in female <i>ABCA1</i> and <i>LCAT</i> mutation carriers compared to age-matched female controls.
<p>Data are presented as mean ± SD. P values for student’s t-test.</p
Peak serum cortisol increase after cosyntropin administration in female <i>ABCA1</i> and <i>LCAT</i> mutation carriers versus female controls.
<p>Data are presented as mean ± SD. P values for Student’s T-test.</p