2 research outputs found
Electrochemical DNA biosensors – useful diagnostic tools for the detection of damage to DNA caused by organic xenobiotics (a review)
Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the
electrochemical investigation of interactions between studied analytes and DNA. Observing the
pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics
provides good evidence for the interaction mechanism to be elucidated. Such interaction can
also be used for sensitive determination of these compounds. This short review should provide
evidence that the electrochemical approach brings new insight into human health protection or
rational drug design and leads to further understanding of the interaction mechanism between
organic xenobiotic compounds and DNA
Simulation Models in a Fluidity Test of the Al-Si Alloy
The goal of the fluidity test is to evaluate the ability of the melt to fill the cavity of the mold, which is one of the factors affecting the final quality of the castings. It is a technological test that is basically not standardized, therefore it is realized in different forms, for example using “horizontal” and “vertical” molds. The “horizontal” mold makes it easier to fulfill the condition of repeatability, therefore it was used to calculate the capability of the test by the Measurement Systems Analysis (MSA) method. The results of the tests in both molds were used to calculate regression equations that allow the fluidity to be determined with strong reliability based on variables such as melt temperature, casting speed, and mold temperature. In addition, the effects of input data variability (uncertainty) on the resulting fluidity value were analyzed using regression equations and the Monte Carlo simulation. The contribution of the article is the analysis of the capability of the measurement process of the fluidity and a prediction of the results of its tests using the Monte Carlo simulation method