Por Iuan Francisco y Iuan Andrea Strata y consortes con Iuan Nuñez Sarauia, Diego Aluarez Mendez y Simon Fernandez Lamego y otros, sobre que se reuoque un mandamiento de execucion 4211264 ducados y 19 gruessos de moneda de banco.

Título tomado de la cabecera.Precede al título: cruz griega.En recto de hoja 3 consta el año 1629.Sign.: A-C\p2\s.Texto a línea tirada con capitular ornada y reclamos.Hojas impresas por ambas caras

Fat in left ventricular myocardium assessed by steady-state free precession pulse sequences

Intramyocardial fat can be observed in different pathologic processes including arrhythmogenic right ventricular cardiomyopathy (ARVC) and in old myocardial infarction (OMI) In SSFP images, fat is hyperintense and surrounded by a black boundary, called "Indian Ink" artifact that is generated when fat and water coexist in the same voxel. Aim of this study was to compare the SSFP with the conventional FSE and STIR (FSE/STIR) method for the detection of LV intramyocardial fat. Fifty-four consecutive patients with OMI (>1,000 days) and 69 patients with a diagnosis of ARVC underwent magnetic resonance. LV fat was detected in 29 patients (53.7%) in SSFP images and in 28 patients (51.9%) in FSE/STIR images. At Bland-Altman plot a close agreement was found between the extent of fat measured in SSFP images and in FSE images. However, a slight systematic overestimation, was found for the fat quantification in the SSFP images. In the ARVC group, both FSE/STIR and SSFP images evidenced fat infiltration in LV myocardium in 11 patients (15.9%) without any mismatch. SSFP had 100% sensitivity and 98.8% of specificity to detect LV intramyocardial fat in ARVC and in ischemic heart disease. SSFP sequence with TR/TE = 2 is capable in identifying and quantifying the presence of fat tissue within the LV myocardium in patients with previous myocardial infarction and ARVC. © Springer Science+Business Media, B.V. 2011

Progression of myocardial fibrosis assessed with cardiac magnetic resonance in hypertrophic cardiomyopathy

Objectives This study sought to assess the rate of progression of fibrosis by 2 consecutive cardiac magnetic resonance (CMR) examinations and its relation with clinical variables. Background In hypertrophic cardiomyopathy (HCM) myocardial fibrosis, detected by late gadolinium enhancement (LGE), is associated to a progressive ventricular dysfunction and worse prognosis. Methods A total of 55 HCM patients (37 males; mean age 43 +/- 18 years) underwent 2 CMR examinations (CMR-1 and CMR-2) separated by an interval of 719 +/- 410 days. Extent of LGE was measured, and the rate of progression of LGE (LGE-rate) was calculated as the ratio between the increment of LGE (in grams) and the time (months) between the CMR examinations. Results At CMR-1, LGE was detected in 45 subjects, with an extent of 13.3 +/- 15.2 g. At CMR-2, 53 (96.4%) patients had LGE, with an extent of 24.6 +/- 27.5 g. In 44 patients, LGE extent increased significantly (>= 1 g). Patients with apical HCM had higher increments of LGE (p = 0.004) and LGE-rate (p < 0.001) than those with other patterns of hypertrophy. The extent of LGE at CMR-1 and the apical pattern of hypertrophy were independent predictors of the increment of LGE. Patients with worsened New York Heart Association functional class presented higher increase of LGE (p = 0.031) and LGE-rate (p < 0.05) than those with preserved functional status. Conclusions Myocardial fibrosis in HCM is a progressive and fast phenomenon. LGE increment, related to a worse clinical status, is more extensive in apical hypertrophy than in other patterns. (J Am Coll Cardiol 2012;60:922-9) (C) 2012 by the American College of Cardiology Foundatio