Flow cytometry analysis of MAbs VG-IgG2κ, VG-IgM, and X4 reactivity against the CEA-expressing CO115-5F12 human colon carcinoma cell line (A) and NCA-expressing human granulocytes (B)

<p><b>Copyright information:</b></p><p>Taken from "Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers"</p><p>BMC Cancer 2004;4():75-75.</p><p>Published online 15 Oct 2004</p><p>PMCID:PMC526287.</p><p>Copyright © 2004 Garambois et al; licensee BioMed Central Ltd.</p> 12A11 and 16B10 are two human anti-CEA MAbs that cross-react with NCA. 192 is a murine anti-CEA MAb that cross-reacts with NCA. Binding of the different primary antibodies was detected using either anti-human κ chain, anti-human μ chain, or anti-mouse γ chain as indicated

Precipitation of I-CEA with MAbs VG-IgG2κ (■), VG-IgM (▲), and X4 (●) following incubation in a soluble phase assay

<p><b>Copyright information:</b></p><p>Taken from "Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers"</p><p>BMC Cancer 2004;4():75-75.</p><p>Published online 15 Oct 2004</p><p>PMCID:PMC526287.</p><p>Copyright © 2004 Garambois et al; licensee BioMed Central Ltd.</p

Biodistribution study of I-VG-IgG2κ (■) as compared with I-X4 (○) in LS174T tumor bearing nude mice dissected 24 and 72 h after i

<p><b>Copyright information:</b></p><p>Taken from "Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers"</p><p>BMC Cancer 2004;4():75-75.</p><p>Published online 15 Oct 2004</p><p>PMCID:PMC526287.</p><p>Copyright © 2004 Garambois et al; licensee BioMed Central Ltd.</p>v. co-injection. The tissues shown are (from left to right) tumor, liver, kidneys, lung, spleen, heart, muscle, bone, skin, stomach, low bowel, colon, carcass and blood. Results are expressed in terms of %ID/g ± SD

Potentiation of radiation-induced growth inhibition by letrozole measured by clonogenic assay

<p><b>Copyright information:</b></p><p>Taken from "Letrozole sensitizes breast cancer cells to ionizing radiation"</p><p>Breast Cancer Research 2004;7(1):R156-R163.</p><p>Published online 7 Dec 2004</p><p>PMCID:PMC1064115.</p><p>Copyright © 2004 Azria et al., licensee BioMed Central Ltd.</p> With radiation alone the MCF-7CA cell survival fraction decreased in a dose-dependent manner, which was significantly potentiated by the addition of 0.7 μM letrozole. For 2 Gy radiation, the surviving fraction was 0.66 with radiation alone and was 0.46 with the addition of letrozole (= 0.02). For 3 Gy radiation, the corresponding surviving fractions were 0.4 and 0.18, respectively (= 0.02)

Potentiation of radiation-induced growth inhibition by letrozole measured by the MTT assay

<p><b>Copyright information:</b></p><p>Taken from "Letrozole sensitizes breast cancer cells to ionizing radiation"</p><p>Breast Cancer Research 2004;7(1):R156-R163.</p><p>Published online 7 Dec 2004</p><p>PMCID:PMC1064115.</p><p>Copyright © 2004 Azria et al., licensee BioMed Central Ltd.</p> Growth of MCF-7CA cells, measured 6 days after treatment, was inhibited to a 40% greater extent with letrozole plus 2 Gy radiation, and to a 76% greater extent with letrozole plus 4 Gy radiation, compared with radiation alone

Potentiation of radiation-induced growth inhibition by letrozole measured by cell-count assay

<p><b>Copyright information:</b></p><p>Taken from "Letrozole sensitizes breast cancer cells to ionizing radiation"</p><p>Breast Cancer Research 2004;7(1):R156-R163.</p><p>Published online 7 Dec 2004</p><p>PMCID:PMC1064115.</p><p>Copyright © 2004 Azria et al., licensee BioMed Central Ltd.</p> Growth of MCF-7CA cells, measured for 18 days after treatment, was inhibited to a 76% greater extent with letrozole plus 4 Gy radiation after 12 days, and to an 85% greater extent after 18 days, compared with radiation alone. Solid lines, ■ and ◆ represent radiation alone at 2 Gy and 4 Gy, respectively; dotted lines, ■ and ◆ represent combination of radiation plus letrozole (0.7 μM) at 2 Gy and 4 Gy, respectively