1 research outputs found
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?
Because of the lack of significant
disease-modifying drugs for
neurodegenerative disorders, a pressing need for new chemical entities
endowed with IMAO-B still exists. Within this framework, and for the
first time, a study was performed to compare coumarin- and chomone-3-phenylcarboxamide
scaffolds. Compounds <b>10a</b> and <b>10b</b> were the
most potent, selective, and reversible noncompetitive IMAO-B. The
benzopyrone sp<sup>2</sup> oxygen atom was found to be position independent
and a productive contributor for the ligand–enzyme complex
stability