Health Care Evolves From Reactive to Proactive.

Decoding health and disease pathways drives healthcare evolution. Historically, therapeutic paradigms have relied on interventions that mitigate symptoms of established diseases. Increasingly, molecular insights into pathophysiology now provide unprecedented opportunities to offer curative solutions or even prevent disease and thereby secure longitudinal wellness. These opportunities extend past individual patients to entire populations and geographies. Moreover, they optimize prospective healthspan across lifespan. Linking discovery science and its translatable innovations beyond reactive disease intervention to proactive prevention will maximize society’s returns creating the greatest benefit for the greatest number of people globally

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics.

Clinical Pharmacology & Therapeutics (CPT) is an established voice of the discipline, a trusted source of new knowledge showcasing discovery, translation, and application of novel therapeutic paradigms to advance the management of patients and populations. Identifying, evaluating, prioritizing, and disseminating the best science along the discovery-development-regulatory-utilization continuum are responsibilities shared through peer review. To enhance the uniformity of this essential component of quality assurance and innovation, and maximize the value of the journal and its contents to authors, reviewers, and the readership, we review key concepts concerning peer review as it specifically relates to CPT

Fibonacci Oscillators in the Landau Diamagnetism problem

We address the issue of the Landau diamagnetism problem via $q$-deformed algebra of Fibonacci oscillators through its generalized sequence of two real and independent deformation parameters $q_1$ and $q_2$. We obtain $q$-deformed thermodynamic quantities such as internal energy, number of particles, magnetization and magnetic susceptibility which recover their usual form in the degenerate limit $q_1^2 + q_2^2$=1.Comment: Latex, 11 pages, two figures, version to appear in Physica

Five--Branes and Supersymmetry Breaking in M--Theory

Supersymmetry breaking via gaugino condensation is studied in vacua of heterotic M-theory with five-branes. We show that supersymmetry is still broken by a global mechanism and that the non-perturbative superpotential takes the standard form. When expressed in terms of low energy fields, a modification arises due to a threshold correction in the gauge kinetic function that depends on five-brane moduli. We also determine the form of the low energy matter field Kahler potential. These results are used to discuss the soft supersymmetry breaking parameters, in particular the question of universality.Comment: 28 pages, Late