5 research outputs found
Perfil clínico-epidemiológico de pacientes com Doença de Crohn em uso de terapia biológica de um centro de referência em Salvador, Bahia / Clinical and epidemiological profile of patients with Crohn's disease in biological therapy from a reference center in Salvador, Bahia
Objetivo: Descrever o perfil clínico-epidemiológico dos pacientes com Doença de Crohn em terapia biológica em um centro de referência em Salvador, Bahia. Metodologia: Estudo transversal, realizado entre julho de 2017 e julho de 2018, através da aplicação de questionário e revisão de prontuários de pacientes atendidos em centro de referência em Salvador, Bahia. Foram analisadas variáveis epidemiológicas, classificação de Montreal e Índice de Harvey-Bradshaw. A análise estatística foi realizada utilizando o software SPSS versão 21.0 Resultados: Foram incluídos 116 pacientes com Doença de Crohn, sendo que 50% (N=58) utilizavam terapia biológica. Desses, a maioria era proveniente de zona urbana (87,1%), pardos (55,2%) e negros (32,7%) com renda familiar de até 2 salários mínimos (74,9%), idade média de 39 anos, tempo médio de doença de 94,8 meses, com mesma proporção (50%) de homens e mulheres. Maior parte dos pacientes apresentaram idade ao diagnóstico entre 17-40 anos (75,9%), localização colônica (46,5%), comportamento não estenosante não penetrante (44,6%) e alta taxa de remissão (83,7%). Conclusão: Os pacientes avaliados com doença de Crohn em uso de terapia biológica eram na maioria adultos jovens, procedentes de área urbana, pardos ou negros, com baixa renda familiar, tinham alta frequência de remissão da doença, apresentavam idade ao diagnóstico entre 17-40 anos, localização colônica e doença complicada
P072 Adherence to medical treatment in inflammatory bowel disease in a referral center in Bahia, Brazil
P077 Tuberculosis in inflammatory bowel disease patients from a referral center in Salvador-Bahia, Brazil
Adherence to Medical Treatment in Inflammatory Bowel Disease Patients from a Referral Center in Bahia-Brazil
Background/Aims. Identify the degree of adherence to drug therapy in patients with inflammatory bowel diseases followed up at a referral center in Bahia-Brazil. Methods. Observational, analytical, and cross-sectional studies carried out from June/2017 to July/2018, with questionnaire application and medical record review at a referral center in inflammatory bowel diseases in Salvador, Bahia. The Morisky Green Levine Scale was applied to assess adherence. Mean, standard deviation, and frequency analyses were performed using the statistical package SPSS, and chi-square was used to evaluate the association between categorical variables and adherence degree to treatment. Significant associations were considered with p<0.05. Results. 302 patients with inflammatory bowel diseases were included. Nonadherence was highlighted in the sample. Most part of the study population was female, declared themselves to be mixed race, claimed to be from urban areas, and married. Nonadherence was more frequent than adherence in most sociodemographic variables of the present study. Nonadherence also stood out among the clinical variables, such as disease activity, drug side effect, and use of more than two additional medications. The association between all studied variables and adherence degree to treatment, considering the general sample, did not show statistical significance. When Crohn’s disease and ulcerative colitis patients were evaluated separately, a statistically significant association between nonadherence and female patients with ulcerative colitis was observed. Conclusions. The high frequency of nonadherence was observed in the studied sample. Female gender was associated to nonadherence in the subpopulation with ulcerative colitis
Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil
(1) The aim of the present study was to describe the endoscopic and histopathological findings in the esophagus, stomach, and duodenum in patients with Crohn’s disease. (2) Methods: This was a cross-sectional study that included patients receiving treatment from the inflammatory bowel disease outpatient clinic. Esophagogastroduodenoscopies with biopsies of the stomach and proximal duodenum were performed. Presence of Helicobacter pylori bacteria was assessed by Giemsa staining. (3) Results: We included 58 patients. Erosive esophagitis was identified in 25 patients (43.1%), gastritis was diagnosed in 32 patients (55.2%) and erosive duodenitis was found in eight (13.8%). The most frequent histopathological finding in the H. pylori-positive group was increased inflammatory activity in the gastric body and antrum, with a predominance of mononuclear and polymorphonuclear cells. In turn, the most frequent finding in the H. pylori-negative group was chronic inflammation with predominance of mononuclear cells. Focally enhanced gastritis was identified in four patients (6.9%), all of whom were negative for H. pylori. Granulomas were not observed. H. pylori infection was present in 19 patients (32.8%). (4) Conclusions: Nonspecific endoscopic and histological findings were frequent in patients with Crohn’s disease. Focally enhanced gastritis was uncommon and observed only in H. pylori-negative patients. The time from the diagnosis, patient age, and therapy in use may have influenced the nondetection of epithelioid granuloma