Análise metodológica dos trabalhos de conclusão de curso de Ciências Contábeis da UFPB/JP no triênio 2015–2017, na perspectiva de gênero

The objective of the study was to map the methodologies chosen by the students of the course of Accounting Sciences of Campus 1 of the UFPB to elaborate their Works of Completion of Course, in the period 2015 to 2017, classified by gender. The research on the methodology used is descriptive, bibliographical and documentary, using predominantly quantitative approach. We analyzed 286 CBTs defended during the study period. The data used were accessed through DROPBOX, and abstracts and methodological procedures were extracted by self-declaration. Errors were found in the methodological choices as well as lack of updating of the same since the project stage. Most of the research was documentary and the quantitative and qualitative approaches alternated with gender.O objetivo do estudo foi mapear as metodologias escolhidas pelos discentes do curso de Ciências Contábeis do Campus l da UFPB para elaborar seus Trabalhos de Conclusão de Curso, no período 2015 a 2017, classificados pelo gênero. A pesquisa quanto à metodologia utilizada é descritiva, bibliográfica e documental, utilizando predominantemente abordagem quantitativa. Foram analisados 286 TCC´s defendidos no período estudado. Os dados utilizados foram acessados através do DROPBOX, e extraídas as informações dos resumos e procedimentos metodológicos por autodeclaração. Foram encontrados erros nas escolhas metodológicas bem como falta de atualização das mesmas desde a etapa do projeto. A maioria das pesquisas foram documentais e as abordagens quantitativas e qualitativas alternaram em relação ao gênero

Production and Characterization of a β-Cyclodextrin Inclusion Complex with <i>Platonia insignis</i> Seed Extract as a Proposal for a Gastroprotective System

Platonia insignis Mart, Clusiaceae, known as bacuri, is a species native to Brazil that, in studies with extract of the seed of its fruit, showed antioxidant activity against free radicals. Products with such properties may be of great importance in the treatment of peptic ulcers since this pathology may be associated with the inflammatory process caused by the action of free radicals. Cyclodextrins are molecules capable of forming inclusion complexes with other molecules, affecting their physicochemical properties and improving their pharmacokinetic characteristics. Thus, this work aimed to produce, characterize, and evaluate the gastroprotective effect of the inclusion complex of β-cyclodextrin (β-CD) with the bacuri seeds hexanic extract (BSHE). In the characterization of the inclusion complex, an apparent stability constant (Kc) of 416 mol/L was obtained in the solubility study; the BSHE:β-CD m/m (g) complexation ratios at 1:9, 2:8, and 3:7 were 5.51%, 21.46%, and 20.11%, respectively. The formation of the BSHE:β-CD inclusion complex was observed by FTIR technique, indicating the disappearance of bands characteristic of BSHE (2960 cm−1 and 1755 cm−1) when in the complex, compared to the spectra of pure BSHE or in physical mixture with β-CD, and by X-ray diffraction, which indicated a loss of crystallinity, typical signals of pure β-CD, and presentation of intense amorphization, characteristic of BSHE, incorporated in the β-CD pockets. In the evaluation of gastroprotective activity, through absolute ethanol-induced gastric lesions in mice, both BSHE and BSHE:β-CD reduced gastric lesions, with 100 mg/kg dose of the complex having the greatest gastroprotective effect. BSHE:β-CD was also able to reduce gastric lesions from ischemia and reperfusion, with the 50 mg/kg dose being the most effective. BSHE:β-CD, also at this dose, reduced the MDA levels of the gastric mucosa, indicating a possible antioxidant activity in its gastroprotective effect. Thus, it was concluded that inclusion complex formation between β-CD and BSHE is possible, and that this formulation enhanced the gastric protective activity