7 research outputs found
Inhibition of hemozoin formation by the CQ analogs BAQ and MAQ (mean ± SD from triplicates), in two different experiments.
<p>Statistical differences as compared to drug-free controls are indicated in each graph by an asterisk (p<0.05). The p and r values represent the statistical correlation analyses.</p
Docking energies of the protonated forms of the CQ analogs BAQ and MAQ.
<p>Docking energies of the protonated forms of the CQ analogs BAQ and MAQ.</p
Docking results of NADH and the protonated forms of chloroquine, BAQ and MAQ in the active site of <i>Pf</i>LDH.
<p>Docking results of NADH and the protonated forms of chloroquine, BAQ and MAQ in the active site of <i>Pf</i>LDH.</p
Antimalarial activity of BAQ and MAQ in mice infected with <i>P. berghei</i> after treatment with daily doses of the compounds during three consecutive days.
*<p>Reductions â€30% were considered as inactive, 30â50% as partially active and â„50% as active drugs.</p
Compounds docked in dimeric hematin.
<p>(A) Protonated CQ, (B) MAQ-1, (C) MAQ-2, (D) MAQ-3, (E) BAQ-1, (F) BAQ-2.</p
Cytotoxicity of BAQ and MAQ against a human hepatoma cell line (HEPG2) and a monkey kidney cell line (BGM) determined by the MTT assay.
<p>Data expressed as the minimal lethal dose for 50% of cells (MDL50), used to calculate the selectivity index against either cell.</p>*<p>Selectivity indexâ=âMDL<sub>50/</sub>/IC<sub>50</sub>.</p
The anti-<i>P. falciparum</i> activities of BAQ and MAQ determined in parallel with chloroquine, by the ELISA anti-HRPII assay or by <sup>3</sup>H hypoxanthine incorporation.
<p>All compounds were active at nanomolar doses in both tests.</p><p>IC<sub>50</sub>â=âdose that inhibits 50% of blood parasites growth, evaluated in three or four different experiments for each test.</p