Beyond viral suppression: the quality of life of people living with HIV in Sweden

Sweden has one of the best HIV treatment outcomes in the world and an estimated 95% of all diagnosed people living with HIV are virally suppressed, but the quality of life (QoL) is understudied. The aim of this study was to examine the associations between variables within sociodemographic, behavioural, clinical, psychological, sexual life, social support and personal resource component and the QoL of people living with HIV in Sweden. Data were derived from a cross-sectional, nation-wide survey completed by 15% (n = 1096) of all people living with HIV and collected at 15 infectious disease clinics and 2 needle exchange sites during 2014. Ordinal univariate and multivariate logistic regression analyses were used to examine associations between potential contributors and QoL. Respondents reported high QoL: 63% rated their QoL 7 or higher on a scale ranging from 0 to 10. QoL was independent of gender, age, mode of HIV transmission and country of origin. Lower QoL was associated with recent homelessness, hazardous alcohol consumption, comorbidities, treatment side-effects, HIV-related physical symptoms, hopelessness, negative self-image, sexual dissatisfaction, and negative changes in sex life after HIV. The QoL of people living with HIV in Sweden was high overall, but still significantly influenced by HIV

Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice

OBJECTIVE OF THE STUDY: Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis. METHODOLOGY AND PRINCIPAL FINDINGS: Streptozotocin (STZ)-induced diabetes in apolipoprotein E(-/-) mice resulted in 2.2 fold increased aortic atherosclerosis and enhanced pro-inflammatory burden, as evidenced by elevated blood monocytes, endothelial activation- and inflammatory markers in aorta, and pro-inflammatory cytokines in plasma. In vivo treatment with the NFAT blocker A-285222 for 4 weeks completely inhibited the diabetes-induced aggravation of atherosclerosis, having no effect in non-diabetic mice. STZ-treated mice exhibited hyperglycemia and higher plasma cholesterol and triglycerides, but these were unaffected by A-285222. NFAT-dependent transcriptional activity was examined in aorta, spleen, thymus, brain, heart, liver and kidney, but only augmented in the aorta of diabetic mice. A-285222 completely blocked this diabetes-driven NFAT activation, but had no impact on the other organs or on splenocyte proliferation or cytokine secretion, ruling out systemic immunosuppression as the mechanism behind reduced atherosclerosis. Instead, NFAT inhibition effectively reduced IL-6, osteopontin, monocyte chemotactic protein 1, intercellular adhesion molecule 1, CD68 and tissue factor expression in the arterial wall and lowered plasma IL-6 in diabetic mice. CONCLUSIONS: Targeting NFAT signaling may be a novel and attractive approach for the treatment of diabetic macrovascular complications

Delocalization power of global unitary operations on quantum information

We investigate how originally localized two pieces of quantum information represented by a tensor product of two unknown qudit states are delocalized by performing two-qudit global unitary operations. To characterize the delocalization power of global unitary operations on quantum information, we analyze the necessary and sufficient condition to deterministically relocalize one of the two pieces of quantum information to its original Hilbert space by using only LOCC. We prove that this LOCC one-piece relocalization is possible if and only if the global unitary operation is local unitary equivalent to a controlled-unitary operation. The delocalization power and the entangling power characterize different non-local properties of global unitary operations.Comment: 14 pages, 1 figur

Asymptotic quasinormal modes of Reissner-Nordstr\"om and Kerr black holes

According to a recent proposal, the so-called Barbero-Immirzi parameter of Loop Quantum Gravity can be fixed, using Bohr's correspondence principle, from a knowledge of highly-damped black hole oscillation frequencies. Such frequencies are rather difficult to compute, even for Schwarzschild black holes. However, it is now quite likely that they may provide a fundamental link between classical general relativity and quantum theories of gravity. Here we carry out the first numerical computation of very highly damped quasinormal modes (QNM's) for charged and rotating black holes. In the Reissner-Nordstr\"om case QNM frequencies and damping times show an oscillatory behaviour as a function of charge. The oscillations become faster as the mode order increases. At fixed mode order, QNM's describe spirals in the complex plane as the charge is increased, tending towards a well defined limit as the hole becomes extremal. Kerr QNM's have a similar oscillatory behaviour when the angular index $m=0$. For $l=m=2$ the real part of Kerr QNM frequencies tends to $2\Omega$, $\Omega$ being the angular velocity of the black hole horizon, while the asymptotic spacing of the imaginary parts is given by $2\pi T_H$.Comment: 13 pages, 7 figures. Added result on the asymptotic spacing of the imaginary part, minor typos correcte

Enhancement of singly and multiply strangeness in p-Pb and Pb-Pb collisions at 158A GeV/c

The idea that the reduction of the strange quark suppression in string fragmentation leads to the enhancement of strange particle yield in nucleus-nucleus collisions is applied to study the singly and multiply strange particle production in p-Pb and Pb-Pb collisions at 158A GeV/c. In this mechanism the strange quark suppression factor is related to the effective string tension, which increases in turn with the increase of the energy, of the centrality and of the mass of colliding system. The WA97 observation that the strange particle enhancement increases with the increasing of centrality and of strange quark content in multiply strange particles in Pb-Pb collisions with respect to p-Pb collisions was accounted reasonably.Comment: 8 pages, 3 PostScript figures, in Latex form. submitted to PR

Secure quantum signatures using insecure quantum channels

Digital signatures are widely used in modern communication to guarantee authenticity and transferability of messages. The security of currently used classical schemes relies on computational assumptions. We present a quantum signature scheme that does not require trusted quantum channels. We prove that it is unconditionally secure against the most general coherent attacks, and show that it requires the transmission of significantly fewer quantum states than previous schemes. We also show that the quantum channel noise threshold for our scheme is less strict than for distilling a secure key using quantum key distribution. This shows that “direct” quantum signature schemes can be preferable to signature schemes relying on secret shared keys generated using quantum key distribution.This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) under EP/G009821/1 and EP/K022717/1. P.W. gratefully acknowledges support from the COST Action MP1006. A.K. was partially supported by a grant from FQXi and by Perimeter Institute for Theoretical Physics. Research at Perimeter Institute is supported by the Government of Canada through Industry Canada and by the Province of Ontario through the Ministry of Research and Innovation.This is the author accepted manuscript. The final version is available from the American Physical Society via http://dx.doi.org/10.1103/PhysRevA.93.03232

Fertility of frozen-thawed stallion semen cannot be predicted by the currently used laboratory methods

The aim of the project was to use current simple and practical laboratory tests and compare results with the foaling rates of mares inseminated with commercially produced frozen semen. In Exp. 1, semen was tested from 27 and in Exp. 2 from 23 stallions; 19 stallions participated in both experiments. The mean number of mares per stallion in both experiments was 37 (min. 7, max. 121). Sperm morphology was assessed and bacterial culture performed once per stallion. In Exp. 1, progressive motility after 0, 1, 2, 3, and 4 h of incubation using light microscopy, motility characteristics measured with an automatic sperm analyzer, plasma membrane integrity using carboxyfluorescein diacetate/propidium iodide (CFDA/PI) staining and light microscopy, plasma membrane integrity using PI staining and a fluorometer, plasma membrane integrity using a resazurin reduction test, and sperm concentration were evaluated. In Exp. 2, the same tests as in Exp. 1 and a hypo-osmotic swelling test (HOST) using both light microscopy and a fluorometer were performed immediately after thawing and after a 3-h incubation. Statistical analysis was done separately to all stallions and to those having ≥ 20 mares; in addition, stallions with foaling rates < 60 or ≥ 60% were compared. In Exp. 1, progressive motility for all stallions after a 2 – 4-h incubation correlated with the foaling rate (correlation coefficients 0.39 – 0.51), (p < 0.05). In stallions with > 20 mares, the artificial insemination dose showed a correlation coefficient of -0.58 (p < 0.05). In Exp. 2, the HOST immediately after thawing showed a negative correlation with foaling rate (p < 0.05). No single test was consistently reliable for predicting the fertilizing capacity of semen, since the 2 experiments yielded conflicting results, although the same stallions sometimes participated in both. This shows the difficulty of frozen semen quality control in commercially produced stallion semen, and on the other hand, the difficulty of conducting fertility trials in horses

Decomposing the Sources of Earnings Inequality: Assessing the Role of Reallocation

This paper exploits longitudinal employer-employee matched data from the U.S. Census Bureau to investigate the contribution of worker and firm reallocation to changes in earnings inequality within and across industries between 1992 and 2003. We find that factors that cannot be measured using standard cross-sectional data, including the entry and exit of firms and the sorting of workers across firms, are important sources of changes in earnings distributions over time. Our results also suggest that the dynamics driving changes in earnings inequality are heterogeneous across industries.inequality, linked employer-employee data, sorting

Entanglement of distant optomechanical systems

We theoretically investigate the possibility to generate non-classical states of optical and mechanical modes of optical cavities, distant from each other. A setup comprised of two identical cavities, each with one fixed and one movable mirror and coupled by an optical fiber, is studied in detail. We show that with such a setup there is potential to generate entanglement between the distant cavities, involving both optical and mechanical modes. The scheme is robust with respect to dissipation, and nonlocal correlations are found to exist in the steady state at finite temperatures.Comment: 12 pages (published with minor modifications

Cloning and Joint Measurements of Incompatible Components of Spin

A joint measurement of two observables is a {\it simultaneous} measurement of both quantities upon the {\it same} quantum system. When two quantum-mechanical observables do not commute, then a joint measurement of these observables cannot be accomplished by projective measurements alone. In this paper we shall discuss the use of quantum cloning to perform a joint measurement of two components of spin associated with a qubit system. We introduce a cloning scheme which is optimal with respect to this task. This cloning scheme may be thought to work by cloning two components of spin onto its outputs. We compare the proposed cloning machine to existing cloners.Comment: 7 pages, 2 figures, submitted to PR