Length of stay and mortality associated with healthcare-associated urinary tract infections: a multi-state model

SummaryBackgroundThe emergence of antimicrobial resistance is of particular concern with respect to urinary tract infections, since the majority of causative agents are Gram-negative bacteria. Healthcare-associated urinary tract infections (HAUTIs) are frequently associated with instrumentation of the urinary tract, specifically with indwelling catheters.AimTo evaluate the current incidence, mortality, and length of hospital stay associated with HAUTIs.MethodsA non-concurrent cohort study design was used, conducted between January 1st, 2010 and June 30th, 2014. All patients admitted to one of the eight participating Australian hospitals and who were hospitalized for more than two days were included. The primary outcome measures were the incidence, mortality, and excess length of stay associated with HAUTIs.FindingsFrom 162,503 patient admissions, 1.73% [95% confidence interval (CI): 1.67–1.80] of admitted patients acquired a HAUTI. Using a multi-state model, the expected extra length of stay due to HAUTI was four days (95% CI: 3.1–5.0 days). Using a Cox regression model, infection significantly reduced the rate of discharge (hazard ratio: 0.78; 95% CI: 0.73–0.83). Women were less likely to die (0.71; 0.66–0.75), whereas older patients were more likely to die (1.40; 1.38–1.43). Death was rarer in a tertiary referral hospital compared to other hospitals, after adjusting for age and sex (0.74; 0.69–0.78).ConclusionThis study is the first to explore the burden of HAUTIs in hospitals using appropriate statistical methods in a developed country. Our study indicates that the incidence of HAUTI, in addition to its associated extra length of stay in hospital, presents a burden to the hospital system. With increasing incidence of UTI due to antimicrobial-resistant organisms, surveillance and interventions to reduce the incidence of HAUTI are required

Deformation of the Planetary Orbits Caused by the Time Dependent Gravitational Potential in the Universe

In the paper are studied the deformations of the planetary orbits caused by the time dependent gravitational potential in the universe. It is shown that the orbits are not axially symmetric and the time dependent potential does not cause perihelion precession. It is found a simple formula for the change of the orbit period caused by the time dependent gravitational potential and it is tested for two binary pulsars.Comment: 7 page

Imaging of n-hexane in zeolites by positron emission profiling (PEP)

Positron Emission Profiling (PEP) has been used for in-situ measurement of the surface coverage of H-mordenite by n-hexane, as a function of hexane partial pressure, at the elevated temperatures typically used for hydroisomerization by monitoring the retention time of an injected radio-labelled pulse of n-hexane. The labelled molecules ((CH3C5H11)-C-11) were produced via a two-step alkene homologation reaction in which C-11, produced using a cyclotron, was added to 1-pentene. The PEP method described is similar to the ''tracer pulse technique'' however it has the significant advantage of in-situ imaging of the puls

Response of cereals to fertilizer N on pulse and other stubbles

Non-Peer ReviewedTo optimize cropping systems requires knowledge of effects of the preceding crop on the grain yield and protein and the response to N of a following cereal crop. To gain this knowledge, we grew hard red spring (HRS) wheat, durum wheat, Canadian Prairie Spring (CPS)-class wheat, Canadian Western Extra Strong (CWES)-class wheat, and barley on barley, bean, coriander, fenugreek, kabuli chickpea, lentil, mustard, and pea stubble at different N fertilizer rates over 9 site-yr: Swift Current (1998-2002), Redvers (2001-02), and Canora (1999 and 2002). N rates were medium (recommended rate based on fall soil nitrate in cereal stubble), low (15-30 kg ha-1 less than medium) and high (15-30 kg ha-1). There was a significant effect of stubble on subsequent cereal grain yield. Cereal on cereal stubble was consistently lowest or second lowest yielding (typically 100 – 800 kg ha-1 lower than other stubbles) with the exception of 2001 at Swift Current when it was the highest yielding. This latter effect was attributed to the superior moisture conserving benefits of cereal stubble during this year with extreme early drought. No single cereal crop was consistently highest or lowest yielding. The trend was for greatest grain protein on pulse stubbles although stubble effects on protein were not as great as on yield owing to confounding yield dilution effects. Within this narrow range of fertilizer N rates, yield or protein response to N was weak. Generally, there were no significant interactions between stubble and cereal crop or stubble and fertilizer indicating the effect of stubble was consistent across cereal type and N rates. The cereal yield and protein response to N on the non-cereal stubbles was not significantly different than that on cereal stubble with the exception that barley protein responded more positively to N on lentil stubble than on cereal stubble. Cereals grown on pulse stubbles tended to have higher yields and protein than on other stubbles. For HRS wheat and durum, the chance of achieving high protein grain was greatest with high fertilizer N on pea stubble (>75% of years). Applying a high fertilizer N rate on cereal stubbles did not markedly increase the chance of attaining high protein wheat or durum. For barley, where low protein is desired for malting, the best chance for low protein barley was on cereal and mustard stubble although barley protein appeared less affected by stubble and fertilizer N than wheat or durum

A mobile data acquisition system

A mobile data aquisition (MobiDAQ) was developed for the ATLAS central hadronic calorimeter (TileCal). MobiDAQ has been designed in order to test the functionalities of the TileCal front-end electronics and to acquire calibration data before the final back-end electronics were built and tested. MobiDAQ was also used to record the first cosmic ray events acquired by an ATLAS subdetector in the underground experimental area