Studies of the Helminth Fauna of Norway XXXIV: The morphological stability of Diphyllobothrium Cobbold. A comparison of adult D. dendriticum (Nitzsch), D. latum (L.) and D. ditremum (Creplin) developed in different hosts

Adult D. dendriticum from common gull {Larus canus), herring gull (Larus argentatus) and arctic fox (Alopex lagopus), D. latum from arctic fox, and D. ditremum from merganser (Mergus merganser) were studied. A comparison with worms reared in golden hamster (Mesocrisetus auratus) was conducted. Morphological characters of reliable diagnostic value (characters independent of host and worm population size) are: neck length, type of boundary between neighbouring segments, position of the cirrus-sac in sagittal sections, position of seminal vesicle in relation to the cirrus-sac, and shape of ovary (ovary with or without anterior horns)

The consequences of institutional design on collaborative arrangements’ power to influence urban freight policymaking

Karin Fossheim, Jardar Andersen, The consequences of institutional design on collaborative arrangements’ power to influence urban freight policymaking, Case Studies on Transport Policy, Volume 10, Issue 2, 2022, Pages 1325-1331, ISSN 2213-624X, https://doi.org/10.1016/j.cstp.2022.04.017 (https://www.sciencedirect.com/science/article/pii/S2213624X2200092X)Collaborative governance is becoming increasingly important as a mode of urban freight policymaking. Bringing together actors from private and public sectors in forums makes it possible to move beyond general discussions of delivery challenges to the innovation of joint solutions and lasting improvements to the freight transport system. For such cross-sector collaborations to function, participants must experience a sense of power to influence policy. The institutional design, i.e., the inclusiveness of the collaboration and the interdependence between the participants, may condition this possibility. Consequently, this article investigates how the institutional design of collaborative arrangements associated with urban freight affects participants’ perceptions of power to influence policymaking. We interviewed 37 participants in three different collaborations in Oslo, Norway. The results indicate that institutional design affects participants’ perceptions of power to influence policymaking. Inclusive collaborations, in which participants are not interdependent, provide participants with the most power to influence policy, rather than exclusive collaborations, in which participants are highly interdependent.The consequences of institutional design on collaborative arrangements’ power to influence urban freight policymakingpublishedVersio

L’umano in questione / Human in question. Tra ecosofia e teriomorfismo, le derive della carne digitale

Abstract not aivailabl

In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses

Intra-articular administration of sustained-release anti-inflammatory drugs is indicated in horses suffering from joint inflammation, but no such drugs are labelled for veterinary use. To obtain initial data on synovial disposition and safety of a new sustained-release formulation of diclofenac (SYN321) in the joints of horses, an experimental interventional study of elimination and side effects of intra-articular administration of SYN321 was conducted. Nine clinically sound horses were included in the study, and SYN321 was administered by the intra-articular route. Dose ranges and sampling intervals were established in a pilot study with two horses, and then applied in a main study involving seven horses treated in the fetlock joint. Diclofenac was detected above lower limit of quantification (LOQ: 0.5 ng/ml) in synovial fluid throughout the study period (14 days), and below LOQ (0.1 ng/ml) in plasma after 4 days and in urine after 14 days. No obvious clinical side effects were detected. Clinical examination and objective lameness evaluation suggested that SYN321 has potential as a local joint NSAID treatment with sustained release in horses, but further studies on synovial fluid exposure, safety and clinical efficacy are warranted

Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis

The most common cause of amyotrophic lateral sclerosis (ALS) is mutations in superoxide dismutase-1 (SOD1). Since there is evidence for the involvement of non-neuronal cells in ALS, we searched for signs of SOD1 abnormalities focusing on glia. Spinal cords from nine ALS patients carrying SOD1 mutations, 51 patients with sporadic or familial ALS who lacked such mutations, and 46 controls were examined by immunohistochemistry. A set of anti-peptide antibodies with specificity for misfolded SOD1 species was used. Misfolded SOD1 in the form of granular aggregates was regularly detected in the nuclei of ventral horn astrocytes, microglia, and oligodendrocytes in ALS patients carrying or lacking SOD1 mutations. There was negligible staining in neurodegenerative and non-neurological controls. Misfolded SOD1 appeared occasionally also in nuclei of motoneurons of ALS patients. The results suggest that misfolded SOD1 present in glial and motoneuron nuclei may generally be involved in ALS pathogenesis