376 research outputs found
Dose verification of radiotherapy for lung cancer by using plastic scintillator dosimetry and a heterogeneous phantom
Get PDFTeaching Power Electronics with a Design-Oriented and Project-Based Learning Method at the Technical University of Denmark
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Automated four-dimensional Monte Carlo workflow using log files and real-time motion monitoring
Get PDFFiber optically coupled radioluminescence detectors: A short review of key strengths and weaknesses of BCF-60 and Al2O3:C scintillating-material based systems in radiotherapy dosimetry applications
Get PDFRelating ionization quenching in organic plastic scintillators to basic material properties by modelling excitation density transport and amorphous track structure during proton irradiation
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Comparative pharmacology of a new recombinant FSH expressed by a human cell line
Get PDFRecombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylation, and have distinct pharmacokinetic and pharmacodynamic profiles in women. Comparative experiments demonstrated that follitropin delta and follitropin alfa displayed the same in vitro potency at the human FSH receptor, but varied in their pharmacokinetics in mouse and rat. While follitropin delta clearance from serum depended in part on the hepatic asialoglycoprotein receptor (ASGPR), follitropin alfa clearance was unaffected by ASGPR inhibition in rat or genetic ablation in mice. The distinct properties of follitropin delta and follitropin alfa are likely to contribute to the differing pharmacokinetic and pharmacodynamic profiles observed in women and to influence their efficacy in therapeutic protocols for the treatment of infertility
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