Effect of mulberry leaves on diabetes

ABSTRACT Mulberry leaves, rich in protein, fibre, minerals and vitamins C, contain trigonelline bases, glycoprotein Moran A, which have been found to possess antidiabetic effect. Inclusion of the dried leaf powder at 25% level in the diet of diabetic rats for a period of 60 days, significantly decreased blood glucose, glycosylated haemoglobin (HbA 1c ) and activities of serum enzymes viz., lactate dehydrogenase, acid and alkaline phosphatases, glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT)

The efficacy and safety study of dietary supplement PURIAM110 on non-insulin taking Korean adults in the stage of pre-diabetes and diabetes mellitus: protocol for a randomized, double-blind, placebo-controlled, and multicenter trial-pilot study

<p>Abstract</p> <p>Background</p> <p>Diabetes has already become a threat to the nation and the individual due to its high prevalence rates and high medical expenses. Therefore, preventing diabetes at an earlier stage is very important. Despite advances in antidiabetic agents, we have not yet achieved any satisfying results in treating diabetes. Among various treatments, medicinal herbs and supplements for diabetes are reported to show generally good efficacy and safety data. In particular, PURIAM110, a compound from orange fruits and mulberry leaves, is supposed to prevent the progress of type II diabetes mellitus and improve diabetic symptoms. This is the first reported pilot study about the protective effect of the orange fruits and mulberry leaves mixture against pre-diabetes on Korean adults. Based on these positive results of herb-derived components, extended studies of dietary supplements have to be done to suggest confirmative evidences.</p> <p>Methods/Design</p> <p>The efficacy and safety study of PURIAM110 is a double-blinded, placebo-controlled, randomized, and multi-center clinical trial. A total of 45 subjects will participate in this study for 6 weeks.</p> <p>Discussion</p> <p>The present protocol will confirm the efficacy and safety of PURIAM110 for pre-diabetes, suggesting more basic knowledge to conduct further randomized controlled trials (RCT). In addition, PURIAM110 can be an alternative dietary supplemental remedy for diabetes patients.</p> <p>Trial Registration</p> <p>ISRCTN: <a href="http://www.controlled-trials.com/ISRCTN44779824">ISRCTN44779824</a></p

Hypoglycemic, diuretic and hypocholesterolemic effect of Winter cherry (<i>Withania somnifera, </i>Dunal) root

607-609Hypoglycemic, diuretic and hypocholesterolemic effects of roots of W. somnifera (ashvagandha) were assessed on human subjects. Six mild NIDDM subjects and six mild hypercholesterolemic subjects were treated with the powder of roots of W.somnifera for 30 days. Suitable parameters were studied in the blood and urine samples of the subjects along with dietary pattern before and at the end of treatment period. Decrease in blood glucose was comparable to that of an oral hypoglycaemic drug. Significant increase in urine sodium, urine volume, significant decrease in serum cholesterol, triglycerides, LDL (low density lipoproteins) and VLDL (very low density lipoproteins) cholesterol were observed indicating that root of W.somnifera is a potential source of hypoglycemic, diuretic and hypocholesterolemic agents. Clinical observations revealed no adverse effects

<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">Control of hyperglycemia and retardation of cataract by mulberry(<i>Marus indica L</i>.) leaves in streptozotocin diabetic rats</span>

791-795<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:black;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Dried leaf powder of mulberry (M. indica L.) when given along with the diet at 25% level to streptozotocin induced diabetic male Wistar albino rats for 8 weeks, controlled hyperglycemia, glycosuria, albuminuria and retarded onset of retinopathy. Untreated diabetic rats showed hyperglycemia, glycosuria, albuminuria and developed lenticular opacity after 8 weeks of experimental period.</span

Bioactive phytoconstituents in methanolic extract and ethyl acetate fraction of methanolic extract of coriander (Coriandrum sativum L.) seeds

Abstract Identifying bioactive compounds and establishing their health effects are active areas of scientific inquiry. The discovery of novel health effects of bioactive compounds will provide the scientific basis for future efforts to use biotechnology to modify/fortify foods and food components as a means to improve pu blic health. Coriander is one of the oldest spices, possessing multiple traditional health benefits. The present investigation was aimed to identify some of the phenolic compounds present in the methanolic extract of coriander seeds using various analytical techniques. The RP-HPLC analysis revealed chlorogenic acid to be predominant in the extract, followed by rutin, caffeic acid and quercetin. High performance thin layer chromatography (HPTLC) of ethyl acetate fraction revealed the presence of many phenolic compounds, out of which quercetin and rutin could be identified and quantified; rutin being predominant in the fraction, followed by quercetin. Analysis using nuclear magnetic resonance (NMR) spectroscopy through 1 H, 13 C, and IR spectra indicated the E2 compound (obtained from ethyl acetate fraction) to be hydrocarbon in nature. Thus, coriander (Coriandrum sativum L.) seeds are a promising source of phytochemicals with wide applications in the prevention and treatment of diseases induced by free radicals

Oxidative stress in NIDDM patients: influence of coriander (Coriandrum sativum) seeds.

ABSTRACT Oxidative stress is increased in diabetic patients since persistent hyperglycemia causes an increased production of oxygen free radicals through autoxidation of glucose and non-enzymatic glycation of proteins. Increased levels of the products of oxidative damage to lipids and proteins have been detected in the serum of diabetic patients. Administration of coriander seeds (5g/day) to NIDDM patients for 60 days countered oxidative stress as evidenced by significantly decreased lipid peroxidation, protein oxidation and decreased activity of erythrocyte catalase (CAT), increased serum carotene, vitamin A, E and C in diabetics treated with coriander seeds. Besides, the treatment increased the activity of erythrocyte antioxidant enzyme i.e. glutathione-Stransferase (GST) and reduced glutathione content (GSH) in the treated diabetics. In conclusion, the treatment with coriander seeds ameliorated oxidative stress in diabetics due to the synergistic action of antioxidant phytochemicals, carotenoids, flavonoids etc. present in the seeds. From the findings of the study, the seeds are identified to possess antioxidant potential and hence, may be prescribed as adjunct to dietary therapy to combat oxidative stress in NIDDM patients