Earth Observation in the EMMENA Region: Scoping Review of Current Applications and Knowledge Gaps

Earth observation (EO) techniques have significantly evolved over time, covering a wide range of applications in different domains. The scope of this study is to review the research conducted on EO in the Eastern Mediterranean, Middle East, and North Africa (EMMENA) region and to identify the main knowledge gaps. We searched through the Web of Science database for papers published between 2018 and 2022 for EO studies in the EMMENA. We categorized the papers in the following thematic areas: atmosphere, water, agriculture, land, disaster risk reduction (DRR), cultural heritage, energy, marine safety and security (MSS), and big Earth data (BED); 6647 papers were found with the highest number of publications in the thematic areas of BED (27%) and land (22%). Most of the EMMENA countries are surrounded by sea, yet there was a very small number of studies on MSS (0.9% of total number of papers). This study detected a gap in fundamental research in the BED thematic area. Other future needs identified by this study are the limited availability of very high-resolution and near-real-time remote sensing data, the lack of harmonized methodologies and the need for further development of models, algorithms, early warning systems, and services

The ERATOSTHENES Centre of Excellence (ECoE) as a digital innovation hub for Earth observation

The "EXCELSIOR" H2020 Widespread Teaming Phase 2 Project: ERATOSTHENES: EXcellence Research Centre for Earth SurveiLlance and Space-Based MonItoring Of the EnviRonment is supported from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 857510 for a 7 year project period to establish a Centre of Excellence in Cyprus. As well, the Government of the Republic of Cyprus is providing additional resources to support the establishment of the ERATOSTHENES Centre of Excellence (ECoE) in Cyprus. The ECoE seeks to fill the gap by assisting in the spaceborne Earth Observation activities in the Eastern Mediterranean and become a regional key player in the Earth Observation (EO) sector. There are distinct needs and opportunities that motivate the establishment of an Earth Observation Centre of Excellence in Cyprus, which are primarily related to the geostrategic location of the European Union member state of Cyprus to examine complex scientific problems and address user needs in the Eastern Mediterranean, Middle East and Northern Africa (EMMENA), as well as South-East Europe. An important objective of the ECoE is to be a Digital Innovation Hub and a Research Excellence Centre for EO in the EMMENA region, which will establish an ecosystem where state-of-the-art sensing technology, cutting-edge research, targeted education services, and entrepreneurship come together. It is based on the paradigm of Open Innovation 2.0 (OI2.0), which is founded on the Quadruple Helix Model, where Government, Industry, Academia and Society work together to drive change by taking full advantage of the cross-fertilization of ideas. The ECoE as a Digital Innovation Hub (DIH) adopts a two-axis model, where the vertical axis consists of three Thematic Clusters for sustained excellence in research of the ECoE in the domains of Atmosphere and Climate, Resilient Societies and Big Earth Data Management, while the horizontal axis is built around four functional areas, namely: Infrastructure, Research, Education, and Entrepreneurship. The ECoE will focus on five application areas, which include Climate Change Monitoring, Water Resource Management, Disaster Risk Reduction, Access to Energy and Big EO Data Analytics. This structure is expected to leverage the existing regional capacities and advance the excellence by creating new programs and research, thereby establishing the ECoE as a worldclass centre capable of enabling innovation and research competence in Earth Observation, actively participating in Europe, the EMMENA region and the global Earth Observation arena. The partners of the EXCELSIOR consortium include the Cyprus University of Technology as the Coordinator, the German Aerospace Center (DLR), the Leibniz Institute for Tropospheric Research (TROPOS), the National Observatory of Athens (NOA) and the Department of Electronic Communications, Deputy Ministry of Research, Innovation and Digital Policy

On the development of physiologically based toxicokinetic (PBTK) models for cardiovascular implants

Local and systemic contamination caused by metal ions leaching from medical device materials is a significant and continuing health problem. The increasing need for verification and validation, and the imposition of stringent government regulations to ensure that the products comply with the quality, safety, and performance standards, have led regulatory bodies worldwide to strongly recommend the use of modeling and simulation tools to support medical device submissions. A previously published physiologically based toxicokinetic (PBTK) model, is here expanded and enriched by an additional separate tissue compartment to better resemble normal physiology and by the introduction of time-dependent functions to describe all biokinetic parameters. The new model is exercised in conjunction with state-of-the-art probabilistic, Monte Carlo methodology to calculate the predictions' confidence intervals and incorporate variability associated with toxicological biodistribution studies. The quantitative consistency of the model-derived predictions is validated against reported data following the implantation of nickel-containing cardiovascular devices in humans and minipigs. Finally, a new methodology for compartmental toxicological risk assessment is presented that can be used for forward or reverse dosimetry. Our work is aimed at providing a computational tool to optimize the device design characteristics and safeguard that the substances released do not exceed permissible exposure limits

Preventing maritime transport of pathogens: The remarkable antimicrobial properties of silver-supported catalysts for ship ballast water disinfection

Ship ballast water (SBW) antimicrobial treatment is considered as a priority issue for the shipping industry. The present work investigates the possibility of utilizing antimicrobial catalysis as an effective method for the treatment of SBW. Taking into account the well-known antimicrobial properties of ionic silver (Ag+), five silver-supported catalysts (Ag/gamma-Al2O3) with various loadings (0.05, 0.1, 0.2, 0.5, and 1 wt%) were prepared and examined for the antimicrobial treatment of SBW. The bactericidal activity of the aforementioned catalysts was investigated towards the inhibition of Escherichia coli (Gram-negative) and Escherichia faecalis (Gram-positive) bacteria. Catalytic experiments were conducted in a three-phase continuous flow stirred tank reactor, used in a semi-batch mode. It was found that using the catalyst with the lowest metal loading, the inhibition of E. coli reached 95.8% after 30 minutes of treatment of an E. coli bacterial solution, while the inhibition obtained for E. faecalis was 76.2% after 60 minutes of treatment of an E. faecalis bacterial solution. Even better results (100% inhibition after 5 min of reaction) were obtained using the catalysts with higher Ag loadings. The results of the present work indicate that the prepared monometallic catalysts exert their antimicrobial activity within a short period of time, revealing, for the first time ever, that the field of antimicrobial heterogeneous catalysis using deposited ionic silver on a solid support may prove decisive for the disinfection of SBW

A Predictive Toxicokinetic Model for Nickel Leaching from Vascular Stents

In vitro testing methods offer valuable insights into the corrosion vulnerability of metal implants and enable prompt comparison between devices. However, they fall short in predicting the extent of leaching and the biodistribution of implant byproducts under in vivo conditions. Physiologically based toxicokinetic (PBTK) models are capable of quantitatively establishing such correlations and therefore provide a powerful tool in advancing nonclinical methods to test medical implants and assess patient exposure to implant debris. In this study, we present a multicompartment PBTK model and a simulation engine for toxicological risk assessment of vascular stents. The mathematical model consists of a detailed set of constitutive equations that describe the transfer of nickel ions from the device to peri-implant tissue and circulation and the nickel mass exchange between blood and the various tissues/organs and excreta. Model parameterization was performed using (1) in-house-produced data from immersion testing to compute the device-specific diffusion parameters and (2) full-scale animal in situ implantation studies to extract the mammalian-specific biokinetic functions that characterize the time-dependent biodistribution of the released ions. The PBTK model was put to the test using a simulation engine to estimate the concentration-time profiles, along with confidence intervals through probabilistic Monte Carlo, of nickel ions leaching from the implanted devices and determine if permissible exposure limits are exceeded. The model-derived output demonstrated prognostic conformity with reported experimental data, indicating that it may provide the basis for the broader use of modeling and simulation tools to guide the optimal design of implantable devices in compliance with exposure limits and other regulatory requirements

Regulating the catalytic properties of Pt/Al2O3 through nanoscale inkjet printing

For the first time ever, a 0.1 wt% Pt/Al2O3 catalyst was prepared by novel inkjet printing and compared against two catalysts prepared by a standard and modified wet impregnation method. The printed catalyst was found to present excellent activity and wide operating temperature window on the selective catalytic reduction of NO by H2 under strongly oxidizing conditions (H2-SCR) in the very low-temperature range of 100–200 °C. The transient studies performed in the present work indicated that the printing process followed led to a unique surface structure of the printed catalyst that probably favors the formation of different active intermediate NOx species, which are active at very low reaction temperatures. Moreover, it was found that the inkjet printing protocol followed resulted in a relatively uniform nano-spherical structure of the developed catalyst

Rapid Velocity-Encoded Cine Imaging with Turbo-BRISK

Velocity-encoded cine (VEC) imging is potentially an important clinical diagnostic technique for cardiovascular diseases. Advances in gradient technology combined with segmentation approaches have made possible breathhold VEC imaging, allowing data to be obtained free of respiratory artifacts. However, when using conventional segmentation approaches, spatial and temporal resolutions are typically compromised to accommodate short breathhold times. Here we apply a sparse sampling technique, turbo-BRISK (i.e., segmented block regional interpolation scheme for k-space) to VEC imaging, allowing increased spatial and temporal resolution to be obtained in a short breathhold period. BRISK is a sparse sampling technique with interpolation used to generate unsampled data. BRISK was implemented to reduce the scan time by 70 % compared with a conventional scan. Further, turbo-BRISK scans, using segmentation factors up to 5, reduce the scan time by up to 94%. Phantom and in vivo results are presented that demonstrate the accuracy of turbo-BRISK VEC imaging. In vitro validation is performed using conventional magnetic resonance VEC. Pulsatile centerline Jrow velocity measurements obtained with turbo-BRISK acquisitions were correlated with conventional magnetic resonance imaging measurements and achieved r values of 0.99 rt 0.004 (mean 2 SD) with stroke volumes agreeing to within 4%. A potential limitation of BRISK is reduced accuracy for rapidly varying velocity projles. We present low- and high-resolution data sets to illustrate the resolution dependence of this phenomenon and demonstrate that at conventional resolutions, turbo-BRISK can accurately represent rapid velocity changes. In vivo results indicate that centerline velocity waveforms in the descending aorta correlate well with conventional measurements with an average r value o

Pilot-scale biogas and in-situ struvite production from pig slurry: A novel integrated approach

Excess ammonia produced during the decomposition of nitrogen-rich substrates inhibits the anaerobic digestion (AD) process while it increases the concentration of ammonium nitrogen (NH4+) in the digestate. Digestate is commonly applied to farmland, causing nitrogen loss via runoff and volatilization. Therefore, developing an integrated strategy to promote the overall efficiency of AD systems susceptible to ammonia toxicity events, is worthy of consideration. Herein, a step-feeding approach to combat ammonia toxicity in AD process in which, intermittent rather than continuous substrate feeding was tested. A pilot-scale, mesophilic (37 ± 1 °C), fed-batch AD reactor (working volume ∼ 6.67 m3), was operated as the biomethanation step in a novel biorefinery concept, to recover bioenergy and nutrients (struvite) from pig slurry. The results showed that methane production yield achieved was 89.7 % of the theoretical at high ammonia levels (4.44 g NH4+-N L−1), indicating an efficient AD process under strong ammonia stress. The production rate of precipitate was 4.0 kg t−1 feedstock, while X-Ray Diffraction analysis revealed that purity of struvite crystal was 98 % w/w. Orthorhombic crystals and homogeneous distribution of significant elements (O, P, N, and Mg) in the precipitate were observed through scanning electron microscopy coupled with energy dispersive X-ray analysis. Recoveries of nitrogen and phosphorus were 48.5 % and 68.5 % from the digestate, respectively. Furthermore, the chemical and sanitary (i.e., Escherichia coli, Enterobacteriaceae and Salmonella) indicators of the precipitate were in line with the EU Fertilizer Regulation. Overall, the obtained results indicate that it is possible to establish an integrated efficient nutrient and energy recovery process for the simultaneous production of high-yield biogas and high-purity struvite fertilizer from pig slurry, which could yield a gross profit of 5.79 € t−1 feedstock