Characteristics of ICMD participants by age: Menopausal status, BMI, and measures of mammographic density.

<p>Characteristics of ICMD participants by age: Menopausal status, BMI, and measures of mammographic density.</p

Difference in square-root mammographic density measures in postmenopausal compared to premenopausal women and by time since menopause: Overall and in subgroups (pooled analyses).

<p>Difference in square-root mammographic density measures in postmenopausal compared to premenopausal women and by time since menopause: Overall and in subgroups (pooled analyses).</p

Difference in square-root mammographic density measures with a 10-year difference in age, in pre- and postmenopausal women.

<p>Difference in square-root mammographic density measures with a 10-year difference in age, in pre- and postmenopausal women.</p

Polynomial smoothed curves of the crude association of percent mammographic density with age, for each population group within broad ethnic groups.

<p>The broad ethnic groups are organised from largest (black women) to smallest (East Asian women) average breast area for BMI. Full names and details of studies/population groups presented in this figure are provided in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002335#pmed.1002335.s011" target="_blank">S1 Text</a>). Adjustments: none. PD, percent mammographic density.</p

Modelled associations of square-root percent density, dense area, and total breast area with age and menopausal status, overall and by subgroups.

<p>Square-root dense/breast area is the width of a square representing the dense/breast area; square-root PD is the width of a dense-area square within a 10 cm × 10 cm square. All models are adjusted for age, BMI, BMI2, parity, age at first birth, HRT use (never, ever, past, current, not known), MD reader, image type, and mammography view. BMI, body mass index; CI, confidence interval; ICMD, International Consortium on Mammographic Density;HRT, hormone replacement therapy; MD, mammographic density.</p

Association of square-root percent mammographic density with menopausal status and age.

<p>Associations of square-root percent density, by population group, with (a) menopausal status, (b) age among premenopausal women, and (c) age among postmenopausal women, meta-analysed overall and by ASR in source population (low, medium, high). Associations are adjusted for age (for [a] only), BMI, BMI2, parity, age at first birth, HRT use (never, current, former, ever, unknown), mammography view, and MD reader. Full names and details of studies/population groups presented in this figure are provided in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002335#pmed.1002335.s011" target="_blank">S1 Text</a>. Chile is excluded from (a) and (c) as all women were premenopausal. Norway, Australia (Greek), and Australia (Italian) were not included in (a) and (b) as all women were postmenopausal. Turkey was excluded from (a) as selection of women implied that age completely determined menopausal status. ASR, age-standardised incidence rate; BMI, body mass index; CI, confidence interval; HRT, hormone replacement therapy; MD, mammographic density; PD, percent mammographic density.</p