Relation between Plasma <i>R249S-</i>mutated <i>DNA</i> and HBs-antigen (HBsAg) and HCV-antibody (HCV-ab).

<p><i>X₂</i> test when compared to cholangiocarcinoma, chronic liver disease and reference group all together (*: p value <0.05; ***: p value <0.001; NA: Not Available; ns: non significant).</p

Geographic distribution of liver cancer cases.

<p>Dots represent the distribution by province. Pie charts describe the distribution of HCC/no cirrhosis (lines), HCC/cirrhosis (full black) and CC (small dots) among the Northwest, Northeast and Central-south parts of the country.</p

Relation between Plasma <i>R249S-mutated DNA</i> and AFP.

*<p><i>X₂</i> test comparing individuals with <i>R249S</i> > = 150 copies/mL against individuals with <i>R249S</i> <150 copies/mL.</p

Box and whisker distributions of <i>TP53 R249S</i>-<i>mutated DNA plasma concentrations</i> (≥150 copies/mL) for the different groups.

<p>Boxes extend from 25^th to 75^th percentiles and are divided by a solid line representing the median of each centre. The median levels for the different groups are: 328 in HCC/no cirrhosis, 273 in HCC/cirrhosis, 252 in CC, 256 in CLD and 202 in R.</p