Eclipse Ballooning STEM Outreach for Elementary, Middle, and High School Education

To promote Science, Technology, Engineering and Mathematics (STEM) education through ballooning, the North Dakota Space Grant Consortium (NDSGC) organizes an annual Near-Space Balloon Competition (NSBC) for students in grades 6 - 12. Students across the state of North Dakota have the opportunity to launch experiments into a near- space environment. The students learn how to write proposals, design payloads, and analyze data. They learn through an active, inquiry-based style that will prepare them for real-world engineering and critical thinking jobs. In 2016, NSBC proposed Great American Eclipse as the theme for the competition, thus the students were focused on designing heliocentric payloads. To promote STEM education to students of all ages, North Dakota Atmospheric and Educational Student Initiated Research (ND-AESIR) team partnered with third grade classes in a North Dakota tribal community for a balloon launch during the 2017 total solar eclipse. Students submitted ping pong balls, which were filled with items of personal and cultural significance. The initiative allowed students to be involved in a space mission and educate them about space. ND-AESIR flew the ping pong balls as a secondary payload during the total solar eclipse from Rexburg, Idaho. After the successful launch and retrieval of the payloads, the ping pong balls were returned to the students, who can now say that their treasured items have touched near space! These two outreach projects took advantage of the opportunity to focus on a rare astronomical event, providing an unique venue to inspire the students towards STEM involvement

Development of Remotely Operated Sensor based Greenhouse for Planetary Habitat Research

The Inflatable Lunar/Mars Habitat (ILMH) located at the University of North Dakota is an operational planetary base concept developed to perform simulations of lunar and Mars missions. The ILMH is also equipped with a rover and two NDX-2AT space suits to perform extravehicular operations. The ILMH is used to conduct planetary analog missions for up to four crew members. Four additional modules are being added to the ILMH under a current NASA EPSCoR grant. The additional modules will allow crew members to grow plants, conduct additional extravehicular activities (EVA), perform analysis on geological samples, and maintain human exercise and performance. The Plant Production and EVA modules have already been added to the ILMH in summer of 2017. The additional modules are being developed to mimic feasible extraterrestrial architectures, with the purpose of being tested and optimized on Earth. This paper will describe the engineering challenges of designing a remotely controllable plant sensor system for terrestrial use, from concept to design. The result is a self-sustainable sensor network for the Plant Production module with minimum or no human intervention to be used for extraterrestrial analog simulations. The entire system can be controlled from a remote location. The sensor data can help determine the optimal design of a greenhouse for upcoming missions to settle extraterrestrial bodies

Eclipse Ballooning STEM Outreach for Elementary, Middle, and High School Education

To promote Science, Technology, Engineering and Mathematics (STEM) education through ballooning, the North Dakota Space Grant Consortium (NDSGC) organizes an annual Near-Space Balloon Competition (NSBC) for students in grades 6 - 12. Students across the state of North Dakota have the opportunity to launch experiments into a near- space environment. The students learn how to write proposals, design payloads, and analyze data. They learn through an active, inquiry-based style that will prepare them for real-world engineering and critical thinking jobs. In 2016, NSBC proposed Great American Eclipse as the theme for the competition, thus the students were focused on designing heliocentric payloads. To promote STEM education to students of all ages, North Dakota Atmospheric and Educational Student Initiated Research (ND-AESIR) team partnered with third grade classes in a North Dakota tribal community for a balloon launch during the 2017 total solar eclipse. Students submitted ping pong balls, which were filled with items of personal and cultural significance. The initiative allowed students to be involved in a space mission and educate them about space. ND-AESIR flew the ping pong balls as a secondary payload during the total solar eclipse from Rexburg, Idaho. After the successful launch and retrieval of the payloads, the ping pong balls were returned to the students, who can now say that their treasured items have touched near space! These two outreach projects took advantage of the opportunity to focus on a rare astronomical event, providing an unique venue to inspire the students towards STEM involvement

Solar Eclipse Induced Atmospheric Turbulence Effects on High Altitude Balloons

The North Dakota Atmospheric Education Student Initiated Research (ND-AESIR) team launched a balloon during the total solar eclipse in Rexburg, Idaho. After the umbra’s passage, the balloon experienced unexpectedly high levels of atmospheric turbulence. Video footage taken from the payload displays the conditions, and analysis of flight path data models created from the iridium GPS confirm that unusually violent turbulence occurred. These forces caused the key rings holding the bottom of the parachute to the payload train to rip open; the balloon and parachute flew away and the payloads free fell to the surface from an altitude of 68,301 feet. We hypothesize that the umbra’s passage caused a temperature dip sharp enough to cause a significant pressure differential, creating the ensuing turbulence. Radiosonde data from Montana Space Grant Consortium eclipse balloons and mechanical engineering properties of the key rings will be analyzed. These findings are expected to support our hypothesis and give a better understanding of the specific atmospheric conditions. Future research recommendations include a payload package design to be flown during the next eclipse that includes a suite of instruments to better study the forces behind eclipse induced atmospheric turbulence, in addition to payload connections that can withstand the higher forces experienced in these conditions

COVID-19 in renal transplant patients – A narrative review

The World Health Organisation declared the novel coronavirus known as severe acute respiratory syndrome coronavirus 2 a pandemic in March 2020. This virus has led to the deaths of more than 6 million people worldwide. Besides causing pneumonia, COVID-19 is linked to multiple organ dysfunction, including the kidneys, especially in individuals whose immune systems are already compromised. Consequently, individuals who are currently on a waiting list for a kidney transplant or who have recently received a kidney transplant are at a significantly increased risk for developing acute kidney injury and are severely impacted by the COVID-19 infection. The pandemic has negatively affected the transplantation process and led to a decrease in the number of organ donations as well as the volume of renal transplants. This review summarises the outcomes of COVID-19 infection in renal transplant patients, its pathophysiology, the challenges faced by the transplant community, and the management of immunosuppression

A Meta-Analysis to Assess the Efficacy of HER2-Targeted Treatment Regimens in HER2-Positive Metastatic Colorectal Cancer (mCRC).

Recent trials provide evidence that HER2 is a potential new target for patients with colorectal cancer. While HER2-positive tumors do not show a very encouraging response to anti-HER2-positive agents like trastuzumab alone, promising results have been observed when combined with other synergistically acting tyrosine kinase inhibitors (TKIs). Our meta-analysis was conducted following the Cochrane Handbook and written following the PRISMA guidelines. The protocol was registered on PROSPERO with the registration number CRD42022338935. After a comprehensive search for relevant articles, 14 CTs were identified and uploaded to Rayyan, and six trials were ultimately selected for inclusion. The meta-analysis revealed that a median of three prior lines of therapy was used before enrolling in the six trials comprising 238 patients with HER2-positive metastatic colorectal cancer (mCRC). The pooled objective response rate (ORR) and disease control rate (DCR) were 31.33% (95% confidence interval [CI] 24.27-38.39) and 74.37% (95% CI 64.57-84.17), respectively. The pooled weighted progression-free survival (PFS) was 6.2 months. The pooled ORR and DCR meta-analysis indicate a significant response to HER2-targeted therapy in this patient in HER2-positive mCRC. Additionally, a pooled PFS of 6.2 months suggests that HER2-targeted treatment regimens are associated with a meaningful improvement in survival outcomes in this population

A Meta-Analysis to Assess the Efficacy of HER2-Targeted Treatment Regimens in HER2-Positive Metastatic Colorectal Cancer (mCRC)

Recent trials provide evidence that HER2 is a potential new target for patients with colorectal cancer. While HER2-positive tumors do not show a very encouraging response to anti-HER2-positive agents like trastuzumab alone, promising results have been observed when combined with other synergistically acting tyrosine kinase inhibitors (TKIs). Our meta-analysis was conducted following the Cochrane Handbook and written following the PRISMA guidelines. The protocol was registered on PROSPERO with the registration number CRD42022338935. After a comprehensive search for relevant articles, 14 CTs were identified and uploaded to Rayyan, and six trials were ultimately selected for inclusion. The meta-analysis revealed that a median of three prior lines of therapy was used before enrolling in the six trials comprising 238 patients with HER2-positive metastatic colorectal cancer (mCRC). The pooled objective response rate (ORR) and disease control rate (DCR) were 31.33% (95% confidence interval [CI] 24.27–38.39) and 74.37% (95% CI 64.57–84.17), respectively. The pooled weighted progression-free survival (PFS) was 6.2 months. The pooled ORR and DCR meta-analysis indicate a significant response to HER2-targeted therapy in this patient in HER2-positive mCRC. Additionally, a pooled PFS of 6.2 months suggests that HER2-targeted treatment regimens are associated with a meaningful improvement in survival outcomes in this population

Risks of hypertension and thromboembolism in patients receiving bevacizumab with chemotherapy for colorectal cancer: A systematic review and meta‐analysis

Abstract Background Guidelines show that for metastatic colorectal cancer (mCRC), a combination of three‐drug regimens, fluorouracil, leucovorin, and oxaliplatin and bevacizumab (BVZ), is one of the first‐line standard therapies. BVZ is generally well tolerated; however, it is associated with infrequent, life‐threatening side effects such as severe hypertension (HTN) (5%–18%), Grade ≥3 arterial thromboembolism (ATE) (2.6%), Grade ≥3 hemorrhagic events (1.2%–4.6%), and gastrointestinal perforation (0.3%–2.4%). This meta‐analysis aims to evaluate the additive risk of BVZ‐induced severe HTN and thromboembolism when BVZ is combined with a standard chemotherapy regime in patients with mCRC. Methods Our search was conducted from January 29, 2022, to February 22, 2022, through databases of PubMed, clinicaltrial.gov, EMBASE, Web of Science, and Cochrane Library. Data analysis from randomized controlled trials (RCTs) and clinical trials was conducted using Review Manager V.5.4, comparing BVZ‐chemotherapy to chemotherapy only, focusing on cardiovascular AE such as HTN and arterial and venous thromboembolism. Results The analysis from 26 clinical trials and RCTs showed that the odds of HTN were about four times higher, and ATE subgroup analysis of 11 studies showed over two times higher odds of ATE in patients being treated with BVZ compared to the chemotherapy‐only group. Conclusion BVZ, when added to the standard chemotherapy regimen for mCRC, was associated with higher odds of developing HTN and thromboembolism, specifically ATE, than the chemotherapy‐only group. Our findings are significant as they provide vital information in analyzing the risk–benefit ratio of adding BVZ to the standard chemotherapy regime in patients with mCRC, especially in patients with vascular comorbidities

Risks of hypertension and thromboembolism in patients receiving bevacizumab with chemotherapy for colorectal cancer: A systematic review and meta-analysis.

BACKGROUND: Guidelines show that for metastatic colorectal cancer (mCRC), a combination of three-drug regimens, fluorouracil, leucovorin, and oxaliplatin and bevacizumab (BVZ), is one of the first-line standard therapies. BVZ is generally well tolerated; however, it is associated with infrequent, life-threatening side effects such as severe hypertension (HTN) (5%-18%), Grade ≥3 arterial thromboembolism (ATE) (2.6%), Grade ≥3 hemorrhagic events (1.2%-4.6%), and gastrointestinal perforation (0.3%-2.4%). This meta-analysis aims to evaluate the additive risk of BVZ-induced severe HTN and thromboembolism when BVZ is combined with a standard chemotherapy regime in patients with mCRC. METHODS: Our search was conducted from January 29, 2022, to February 22, 2022, through databases of PubMed, clinicaltrial.gov, EMBASE, Web of Science, and Cochrane Library. Data analysis from randomized controlled trials (RCTs) and clinical trials was conducted using Review Manager V.5.4, comparing BVZ-chemotherapy to chemotherapy only, focusing on cardiovascular AE such as HTN and arterial and venous thromboembolism. RESULTS: The analysis from 26 clinical trials and RCTs showed that the odds of HTN were about four times higher, and ATE subgroup analysis of 11 studies showed over two times higher odds of ATE in patients being treated with BVZ compared to the chemotherapy-only group. CONCLUSION: BVZ, when added to the standard chemotherapy regimen for mCRC, was associated with higher odds of developing HTN and thromboembolism, specifically ATE, than the chemotherapy-only group. Our findings are significant as they provide vital information in analyzing the risk-benefit ratio of adding BVZ to the standard chemotherapy regime in patients with mCRC, especially in patients with vascular comorbidities