3 research outputs found
Alzheimer and Lewy body pathology or Creutzfeldt-Jakob disease
he objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropathological work-up. Neuropathological examination excluded Creutzfeldt-Jakob disease. By contrast other neurodegenerative changes combining Alzheimer-type pathology and Lewy body pathology were detected as the most likely substrate of neurological symptoms. Dementia with Lewy bodies should be included in the differential diagnosis in individuals presenting with rapidly progressive dementia
Neuroectodermal ovarian tumors, A Brief Overview
Primary neuroectodermal tumors of the
ovary are rare monophasic teratomas composed
exclusively or almost exclusively of neuroectodemal
tissue. Approximately 60 neuroectodermal tumors of the
ovary have been reported in the literature. These tumors
were classified as ependymoma, astrocytoma,
glioblastoma multiforme, ependymoblastoma or as
primitive neuroepithelial tumors such as medulloblastoma,
medulloepithelioma and neuroblastoma. Most
tumors were diagnosed in the third and fourth decades of
life, but occasionally they were first discovered in
children, adolescents or older women. Microscopically,
they are identical to equivalent neuroectodermal tumors
of the central nervous system. The review of the
litarature shows that most patients with clinical stage I
and II were treated surgically, whereas those with stage
III or IV tumors received additional radiation or
chemotherapy, or both. The clinical stage at the time of
diagnosis is the most important prognostic parameter of
these tumors