In vitro cytotoxicity and antibacterial activities of cephalosporin tin(II) complexes

Cytotoxicity and antibacterial activities of three novel tin(II) complexes containing cephalosporins: [Sn(cephalothin)Cl], [Sn(cephradine)Cl].H2O and [Sn(cefotaxime)Cl].H2O were investigated against Artemia salina (brine shrimp) and four bacterial strains. The results were compared with the activity of free cephalosporins. The coordination of cephalothin and cephradine to tin(II) ion showed an enhancement of the antibacterial activityColegio de Farmacéuticos de la Provincia de Buenos Aire

Antibacterial activity of cefoperazone metal complexes

Cefoperazone complexes with different metal ions of 1:1 metal to antibiotic stoichiometry have been prepared. The [M(cefopz)CI] complexes (M = Co, Cu and Cd) were characterized by physicochemical and spectroscopic methods. The solubility of the cefoperazone complexes in water and common organic solvents is reduced on complexation. All complexes show higher activity against Salmonella enteritidis. The Co(II) and Cd(II) complexes show better activity in the case of Pseudomonas aeruginosa and Escherichia coli, and Cu(II) and Cd(II) complexes against Shigella sonnei than cefoperazone sodium. The complexes showed to be less active than free cefoperazone against Staphylococcus aureus and Proteus mirabilis.Cefoperazone complexes with different metal ions of 1:1 metal to antibiotic stoichiometry have been prepared. The [M(cefopz)Cl] complexes (M = Co, Cu and Cd) were characterized by physicochemical and spectroscopic methods. The solubility of the cefoperazone complexes in water and common organic solvents is reduced on complexation. All complexes show higher activity against Salmonella enteritidis. The Co(II) and Cd(II) complexes show better activity in the case of Pseudomonas aeruginosa and Escherichia coli, and Cu(II) and Cd(II) complexes against Shigella sonnei than cefoperazone sodium. The complexes showed to be less active than free cefoperazone against Staphylococcus aureus and Proteus mirabilis.Colegio de Farmacéuticos de la Provincia de Buenos Aire