Distribution of three LMP1 characteristics and EBNA1 subtypes in EBV isolates from NPC biopsies.

<p>Distribution of three LMP1 characteristics and EBNA1 subtypes in EBV isolates from NPC biopsies.</p

Alignment of obtained LMP1 sequences isolated from UCNT biopsies.

<p>B95-8* represents aa sequence of the prototype LMP1. Seven characteristic aa positions for variant discrimination, described by Edwards et al. (1999) are underlined. China1 and NC isolates showed additional representative aa changes which were not listed in known classification: China1 (position 322 and 338) and NC (position 338). Of 85 aa substitutions which were identified at additional 58 positions, several were unique for single variant: H→R at 352 for Med-, E→Q at 328 and S at 309 for B95-8, and D→N at 250 for NC.</p

EBNA1 C-terminal nucleotide and amino acid changes found in three subtypes and seven subvariants identified in this study.

<p>EBNA1 C-terminal nucleotide and amino acid changes found in three subtypes and seven subvariants identified in this study.</p

Phylogenetic trees of the C-termini of LMP1 and EBNA1.

<p>(a) Thirty five 506-bp fragments of LMP1 (from coordinates 168719–168213) NPC sequences available in GenBank/EMBL7DDBJ database with accession numbers: JF901794-JF901802, JN971085-JN971091 and KT820429-KT820448 and 13 sequences obtained from GenBank/EMBL7DDBJ database under the following accession numbers: V01555, AY493742, AY493743, AY337721, AY337722, AY493810, AY337723, AY493835, AY337724, AY493799, AY337725, AY337726 and X58140. (b) Forty 329-bp fragments of EBNA1 (from coordinates 109261–109590) NPC sequences available in GenBank/EMBL7DDBJ database with accession numbers KT820449-KT820488 and 10 sequences obtained from GenBank/EMBL7DDBJ database under the following accession numbers: V01555, GU475455, JN986939, AF192742, GU475448, AF192743, GU475431, AF192744, JN986947 and GU475442.</p

Combinations of TNM stages found in UCNT biopsies.

<p>Combinations of TNM stages found in UCNT biopsies.</p