Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease

BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer\u27s disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated. RESULTS: We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and only younger adults exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure. CONCLUSION: PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

DocStories: @foto_historias_

Se trata de un proyecto de innovación docente del grupo de investigación Fotodoc enmarcado en la convocatoria Innova-Docencia 2021/2022 del Vicerrectorado de Calidad de la Universidad Complutense de Madrid. Está formado por 12 personas en total, 9 profesores investigadores (PDI), 2 alumnas y una persona de administración y servicios (PAS). Es un proyecto que reúne a personal de la Facultad de Ciencias de la Información y de la Facultad de Ciencias de la Documentación, e interdisciplinar, ya que está formado por personas expertas en diferentes ámbitos de la comunicación y la documentación: patrimonio fotográfico, ética, comunicación audiovisual, etc. A partir de una plataforma de Instagram @foto_historias_ se pretende trabajar con el alumnado de las asignaturas de Documentación Audiovisual: Perspectivas y Métodos, Documentación fotográfica y audiovisual, Documentación Informativa y Ética y deontología profesional la concienciación sobre la importancia del patrimonio fotográfico, especialmente el doméstico (aquellas fotografías contenidas en álbumes familiares). Se espera que los alumnos y alumnas elijan una fotografía familiar, la escaneen, rastreen su historia y la compartan en la cuenta de Instagram conformando una constelación de foto historias. Las clases magistrales y prácticas (digitalización, conservación, ética y derechos de la imagen) ayudarán a conseguir el objetivo esperado. Además, también se les enseñará a hacer un buen uso de las redes sociales y se intentará fomentar la creatividad y el espíritu crítico

Unidad didáctica la mujer

Ejemplar fotocopiadoUnidad didáctica interdisciplinar sobre la mujer, destinada a la educación de adultos con el objetivo de concienciar a este sector de la población de la problemática real de la mujer. Tras el visionado y comentario de la película Cosas de mujeres, se estudia la unidad en las distintas áreas: lengua y literatura, matemáticas, ciencias sociales y ciencias naturales. Para finalizar con la evaluación de la unidad y una encuesta sobre la mujer.ExtremaduraBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

From student to social worker: A teaching project for self-knowledge and the formation of professional identity in the Degree of Social Work at the Complutense University of Madrid.

El objetivo del proyecto es que el/la estudiante incorpore la mirada sobre una/o misma/o (el autoconocimiento) como herramienta para su desarrollo profesional y su capacidad de modularse en los contextos complejos de su futura intervención social.Depto. de Trabajo Social y Servicios SocialesFac. de Trabajo SocialFALSEsubmitte

Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease

BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer’s disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated. RESULTS: We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and only younger adults exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure. CONCLUSION: PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults.Ministerio de Economía y Competitividad (España)NEUROCENTROFundación La CaixaDepto. de Psicología Experimental, Procesos Cognitivos y LogopediaFac. de PsicologíaTRUEpu

DocStories: @foto_historias_ The Photo Stories exhibition and intergenerational meetings

A partir de las fotografías recogidas en Instagram (@foto_historias_ ) se organizará una exposición fotográfica itinerante comisariada por el alumnado y se llevarán a cabo encuentros intergeneracionales entre estudiantes y escuelas de adultos.Unidad Deptal. de Biblioteconomía y DocumentaciónFac. de Ciencias de la InformaciónFALSEsubmitte

Quorum sensing network in clinical strains of A. baumannii : AidA is a new quorum quenching enzyme

Acinetobacter baumannii is an important pathogen that causes nosocomial infections generally associated with high mortality and morbidity in Intensive Care Units (ICUs). Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen. We analyzed these mechanisms in seven clinical isolates of A. baumannii. Microarray analysis of one of these clinical isolates, Ab1 (A. baumannii ST-2-clon-2010), previously cultured in the presence of 3-oxo-C12-HSL (a QS signalling molecule) revealed a putative QQ enzyme (α/β hydrolase gene, AidA). This QQ enzyme was present in all nonmotile clinical isolates (67% of which were isolated from the respiratory tract) cultured in nutrient depleted LB medium. Interestingly, this gene was not located in the genome of the only motile clinical strain growing in this medium (A. baumannii strain Ab421-GEIH-2010 [Ab7], isolated from a blood sample). The AidA protein expressed in E. coli showed QQ activity. Finally, we observed downregulation of the AidA protein (QQ system attenuation) in the presence of HO (ROS stress). In conclusion, most of the A. baumannii clinical strains were not surface motile (84%) and were of respiratory origin (67%). Only the pilT gene was involved in surface motility and related to the QS system. Finally, a new QQ enzyme (α/β hydrolase gene, AidA protein) was detected in these strains