RETRATO SIN IDENTIFICAR [Material gráfico]

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte, 201

Variations on the Theme of JohnPhos Gold(I) Catalysts: Arsine and Carbene Complexes with Similar Architectures

Arsine and carbene gold­(I) complexes with architectures closely related to those of 2-(di-<i>tert</i>-butylphosphino)­biphenyl gold­(I) complexes have been prepared and structurally characterized. As predicted, 2-(di-<i>tert</i>-butylarsine)­biphenyl gold­(I) complexes are more electrophilic catalysts in comparison to their phosphine analogues, whereas those based on 4-arylindazole behave similarly to NHC-gold­(I) catalysts

Additional file 4: of Along for the ride or missing it altogether: exploring the host specificity and diversity of haemogregarines in the Canary Islands

Table S4 Statistical summary of the variation of haemogregarine prevalence and parasitaemia from Canarian lizards. (DOCX 18 kb

Additional file 2: of Along for the ride or missing it altogether: exploring the host specificity and diversity of haemogregarines in the Canary Islands

Table S2. Uncorrected p-distances between the nine haemogregarine haplotypes discovered in the Canarian lizards. (DOCX 13 kb

MOESM5 of Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012

Additional file 5: Table S4. Multivariable logistic regression models between each asthma-related outcome and having multiple asthma phenotypes, adjusted for co-variables

MOESM3 of Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012

Additional file 3: Table S2. Weighted percentages and comparisons of asthma-related outcomes among subjects with a single asthma phenotype versus: non-classified, and specific combinations of asthma phenotypes

Additional file 1: of Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls

Table S1a. Phthalate metabolite urinary concentrations corrected for specific gravity in a Chilean girls cohort (n = 200). Table S1b. Phenol biomarker urinary concentrations corrected for specific gravity in a Chilean girls cohort (n = 200). Table S2. Geometric mean (95% CI) creatine-adjusted urinary EDC biomarker concentrations and age at measurement in the 2011–2012 U.S. National Health and Nutrition Examination Survey among females 5 to 14 years. Table S3. Spearman correlation between EDC SG-adjusted biomarker urinary concentrations (ng/ml) at B1 and B4 in Chilean cohort (n = 200). Table S4. Sensitivity analysis: menarche hazard ratio (95% CI) associated with log(ng/ml) increase in each EDC biomarker across puberty adjusting for mother's age of menarche. Table S5. Sensitivity analysis: menarche hazard ratio (95% CI) associated with log(ng/ml) increase in biomarker stratified by Tanner stage adjusting for mother's age of menarche. (DOCX 27 kb

Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche

Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome. Nevertheless, the link between early androgen excess and these risk factors remains unknown. Epigenetic modifications, and specifically DNA methylation, have been associated with the initiation and progression of numerous disorders, including obesity and insulin resistance. The aim of this study was to determine if prepubertal androgen exposure is associated with a different methylation profile in pubertal girls. Eighty-six healthy girls were studied. At age 7 y, anthropometric measurements were begun and DHEAS levels were determined. Girls were classified into Low DHEAS (LD) [<42 μg/dL] and High DHEAS (HD) [≥42 μg/dL] groups. At Tanner stages 2 and 4 a DNA methylation microarray was performed to identify differentially methylated CpG positions (DMPs) between HD and LD groups. We observed a differential methylation pattern between pubertal girls with and without biochemical PA. Moreover, a set of DNA methylation markers, selected by the LASSO method, successfully distinguished between HD and LD girls regardless of Tanner stage. Additionally, a subset of these markers were significantly associated with glucose-related measures such as insulin level, HOMA-IR, and glycaemia. This pilot study provides evidence consistent with the hypothesis that high DHEAS concentration, or its hormonally active metabolites, may induce a unique blood methylation signature in pubertal girls, and that this methylation pattern is associated with altered glucose metabolism.</p

Transport activity of Ady2 in <i>S. cerevisiae</i> W303-1A strains: wild-type, <i>dhh1</i>, <i>lsm1</i>, <i>ski7</i>, <i>pat1</i> and <i>nam7</i>.

<p>The results are percentages of initial activities of 2 mM [¹⁴C] acetic acid uptake, pH 5.0. Cells were grown in YNB glucose and derepressed in YNB acetic acid or YNB formic acid. Wild-type and <i>dhh1</i> YNB acetic acid derepressed cells were used as a control.</p

Transport activity of lactic acid in <i>S. cerevisiae</i> W303-1A strains: wild-type, <i>dhh1</i>, <i>jen1</i> (A), <i>lsm1</i>, <i>ski7</i>, <i>pat1</i> and <i>nam7</i> (B).

<p>The results are percentages of initial activities of 2 mM [¹⁴C] lactic acid uptake, pH 5.0. Cells were grown in YNB glucose and derepressed in YNB lactic acid or YNB formic acid. Wild-type and <i>dhh1</i> YNB lactic acid derepressed cells were used as a control.</p