Mechanical behaviour of corrugated laminates

The present research work intends to perform a wide set of structural analyses upon corrugated composite laminated panels and based on these analyses, to assess their mechanical response in correspondence to the constructive solutions, which may range from the composite materials selection to the geometrical features and other modelling parameters. To improve the mechanical performance of those panels one may consider enhancing their geometrical characteristics, their corrugation shape configuration and the materials used to build them. In this latter case, when considering materials selection, laminated composites may also constitute an important alternative. In any case it is considered necessary to assess the impact that each of these parameters may have in the static and in the free vibration behaviour of the structures, in a comprehensive and detailed way. To achieve the main objective of this research work, a comprehensive and diversified set of case studies is considered in order to characterize the influence that each of the modelling, material and geometrical parameters and characteristics may have in the mechanical response of a corrugated panel. This study allowed concluding that for the wide set of design parameters considered, the fibre orientation and corrugation parameters are the ones responsible for the majority of the significantly improved performances.info:eu-repo/semantics/publishedVersio

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained

Obsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol

We conducted a cross-sectional study to compare the prevalence and severity of obsessive-compulsive symptoms (OCSs) and obsessive-compulsive disorder (OCD) in patients with schizophrenia treated with clozapine or haloperidol. Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Axis I disorders-patient edition was used to diagnose schizophrenia and OCD. Sixty subjects, 40 of them using clozapine and 20 using haloperidol, completed the Yale-Brown Obsessive-Compulsive Scale, the Positive and Negative Syndrome Scale (PANSS), and the Clinical Global Impression. The prevalence of OCD in patients taking clozapine was 20%, whereas the prevalence of patients taking haloperidol was 10%, although this difference was not statistically significant (P = .540). However, patients using clozapine showed higher severity of OCSs than patients using haloperidol (P = .027) did. When schizophrenia patients were divided according to the presence or absence of OCD or OCSs, patients with schizophrenia and OCD or OCSs showed higher severity of schizophrenia symptoms when compared to those with schizophrenia without OCD and OCSs (P = .002). A PANSS total score higher than 70 and the use of antidepressants were predictors of the presence of OCSs or OCD. Schizophrenia patients taking clozapine had higher severity scores both in obsessive-compulsive and schizophrenia rating scales. These results may support an association between the exacerbation of obsessive-compulsive phenomena and the use of clozapine. (C) 2009 Elsevier Inc. All rights reserved

Perinatal risk factors and obsessive-compulsive spectrum disorders in patients with rheumatic fever

CAPES/PRODOC, FAPESP[98/15013-9]CAPES/PRODOC, FAPESP[2005/55628-8]CNP