162 research outputs found
Concepts of modern quality systems in a manufacturing company
Universitatea de Stat de Medicină și Farmacie
“Nicolae Testemițanu” din Republica MoldovaIntroducere. Industria farmaceutică este cea mai
strict reglementată industrie din lume, în același timp
aceasta face parte din top 10 industrii mondiale după volumul
de producere și venit. Parțial, investițiile efectuate
cu scopul de dezvoltare a tehnologiilor noi în industrie,
sunt orientate către optimizarea procesului de fabricație,
astfel majoritatea instrumentelor moderne utilizate în
procesul de producere sau sinteză, sunt elaborate inițial
cu atribute de susținere a calității de fabricație. Introducerea
treptată a unor concepte noi în sistemul clasic de
management al calității duce la optimizarea proceselor
tehnologice prin eliminarea maximală a erorilor, facilitarea
creării condițiilor corespunzătoare pentru fabricație,
determinarea punctelor critice, elaborarea strategiilor de
control, îmbunătățirea randamentului producerii și respectiv
la creșterea valorică a întreprinderilor industriale.Introduction. Pharmaceutical industry is one of the
most rigorously regulated industries in the world while
being one of the top ten industries by the manufacturing
volume and also by its revenue. Partially, the investments
that are made with the purpose of developing new manufacturing
technologies are targeted toward the optimization
of manufacturing process and most of the modern
instruments used in either drug manufacturing or the
synthesis processes are initially formulated in order to be
able to assist in ensuring the production quality. Gradual
introduction of new concepts in the classic quality management
system leads to optimization of technological
processes by eliminating the errors, facilitating the establishment
of the appropriate manufacturing conditions,
determining the critical process parameters, drafting
new control strategies, raising the production yield, rising
this way the value of the manufacturing sites
Teeth whitening methods
Introduction: Facial appearance is part of human communication channels. Communication based
on the aesthetic interest our intimate relationships, the family one, the social, professional or unprofessional. Therefore we can not ignore the growing importance that dental aesthetic has. In last few years
whitening methods takes a leading place in treatment of tooth discoloration. The aim of this research is
to study and apply in practice some teeth whitening methods.
Material and methods: 35 patients in age from 18 to 37 were examined (33 women and 4 men with
different tooth discolorations). In order to demonstrate the effectiveness of Opalescence whitening system, own clinical cases have been analyzed.
Results: In all 4 groups of patients, whitening system “Opalescence” has presented good results. All
patients had a decrease of tooth discoloration which was observed form the next visit. In 2 cases, patients
have a temporary hypersensitivity to cold and warm, which was removed by applying gels like Flor Opal
or Ultraeze (Ultradent). Patients have been instructed how to take care of their teeth in order to maintain
newly acquired color. From prophylactic considerations, we recommended fluoride toothpaste “Sensodyne” and whitening toothpaste “Opalescence”.
Results: Analysis of literature data shows that dentists now have multiple methods of treatment for tooth discoloration (veneers, bleaching), but these have to be applied according to the damage degree of dental tissues. Teeth whitening methods require patient monitoring and have to be performed in combination with remineralization therapy
Evalurea factorilor de risc asociaţi aderenţei la tratamentul DOTS Plus
Şcoala de Management în Sănătate Publică USMF „Nicolae Testemiţanu”This paper presents characteristics of multi-drug resistant tuberculosis (MDRTB) in the world, inclusively Moldova; data analysis and interpretation based on nominal data collection stored in the informational system of monitoring and evaluation of tuberculosis cases in Moldova (SIME TB).
Data analysis and interpretation, evaluation of risk factors associated with adherence to treatment of patients with multi-drug resistant tuberculosis enrolled in DOTS Plus treatment in studied sample.
Caracteristica tuberculozei multidrogrezistente în lume şi în Republica Moldova. Analiza şi interpretarea datelor în baza colectării informaţiei nominale stocată în sistemul informaţional de monitorizare şi evaluare a cazurilor de tuberculoză din Republica Moldova (SIME TB).
Analiza şi interpretarea datelor, evaluarea factorilor de risc asociaţi aderenţei la tratament a pacienţilor cu tuberculoză multidrogrezistentă (MDR TB) înrolaţi în tratamentul DOTS Plus în baza eşantionului studiat
Tuberculosis in young population is a priority for public health
Şcoala de Management în Sănătate Publică USMF „Nicolae Testemiţanu”The description of the epidemiological situation regarding tuberculosis among 15 – 29 years old young, for the entire territory of Republic of Moldova for a period of 5 years (2004 to 2008).
The analysis and interpretation of the data from the information stored in the nominal information monitoring and evaluation system of tuberculosis cases (SIME TB). Global morbidity predominantly affects segment of 20 - 29 years old – 81,3%. Alarming figures of multidrug resistant tuberculosis are observed among young new cases – 24,7%. Each day in the Republic of Moldova there are notified 3 new cases of active tuberculosis, one of them with bacillary form, the most dangerous form for the society.
Descrierea situaţiei epidemiologice a tuberculozei în rîndul tinerilor de 15-29 ani pentru întreg teritoriul Republicii Moldova pe perioada de 5 ani (2004 - 2008). Analiza şi interpretarea datelor în baza colectării informaţiei nominale stocata în sistemul informaţional de monitorizare şi evaluare a cazurilor de tuberculoză (SIME TB).
Preponderent morbiditatea globală afectează segmentul de vîrstă 20 – 29 ani în 81,3%. Cifre alarmante de tuberculoză multidrogrezistentă printre cazurile noi în rîndul tinerilor - 24,7%. Fiecare zi în Republica Moldova se notifica 3 cazuri noi de tuberculoză activă, dintre care unul cu forma bacilară, cea mai periculoasă formă pentru societate
Structure and form particularities of interradicular and interdental septa
Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: Interdental and interradicular septa represents anatomical structures that reference
in different types of pathologies like: marginal periodontitis, paradontosis and dental migrations. In
literature does not exist enough information about the structure and form varieties of interalveolar
septa. We can mention next forms of septa: sharp lance form, dome form, crescent form and dissected form
which is divided in: dissected properly and dissected in steps. All this types of forms have a different
influence on pathological appearance on the bone structure. Another particularity is an cortical difference
that may be not so pronounced at some persons, while to others it is more pronounced. Also a particularity
is in the structure of cancellous bone where we can see the distance between bone trabeculae. By time
in some pathological conditions we atest changes in interrdental and interradicular septa - thinning the
cortical at septa's peaks, outbreaks of spongy bone tissue thinning etc.
Purpose: Studying varieties of form and factors that influence their changes at interdental and
interradicular septa's level in normal and pathological cases.
Material and methods: Were studied 132 radiograms of patients that received medical help in
USMF ,,Nicolae Testemitanu" dental clinic and in private dental clinic ,,Parodent Prim" SRL from
Chisinau city. Radiographic clichés were analized at fluoroscopy. For study we used Новик И.О.
classification.The method of collectioning the information was by selective method-were selected only
radiograms that coresponded our classification criteria. Therewith we used the method of observation
and analyze of types of interdental and interradicular septa in norm and pathological disease.
Discussion results: Anatomical structures of interdental and interradicular septa are in strong
relation with various factors: tooth anatomy of teeth and their position in the dental arch, type of
vascularization, local physico-chemical conditions and local systemic factors. The interdental septum
protrude at alveolar level and is more massive in relation with vestibular and oral alveolar wall.
Interradicular septum are perfored by multiple holes, through which nervs and blood vessels pass.
Cortical thickness is reduced at maxillary level than at mandibula. Normally the anatomical structure of
septum is not standart, it has individual particularities (of shape, bone density).
Analyzing the obtained data, we found that from 132 radiograms only 19 (14.39%) of cases was
detected with normal structure interdental and interradiculare septa to young persons - 16-35 years. From
this numbers, dome shaped septum -27,2 %; sharped lance- 25,3 %; halfmoon-46,72% and dissected
shape-0,78%.
Conclusion: 1. The analysis of data from speciality literature that confirms the four types of
interdental septum: dome shaped, halfmoon, sharped lance and dissected shape. 2. The basic factors that
influence the shape of septa are: the teeth anatomy and their position in arch, the functional ocluzal
forces that are transmitted, type of vascularization, physico-chemical conditions of individual local and
systemic factors. 3.Obtained results are in relationship with results from speciality literatury that refers to
the form of septum: dome-27,2%; sharped lance- 25,3%; halfmoon-46,72% and dissected form-
0,78%. 4. Pathological condition mostly apears molars region where prevail the dome shaped septa
Current Concepts on Drug Abuse and Dependence
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about the need for a greater precision in the definition.
Drug dependence can be assigned not only to pharmacological effects of the drugs of abuse, but also to their interaction with each particular neurological and psychological constitution. The research on the neurobiological mechanisms of addiction processes allows both a better understanding of current pharmacotherapy and the development of new treatment strategies in drug abuse and dependence. In this review we intend to present the current concepts related to drug abuse and dependence
HPTLC assay of nicotine and cotinine in biological samples
This study presents the development of a simple high-performance thin layer chromatography (HPTLC) method for the determination of nicotine and its metabolite cotinine in human plasma and urine.
The following mobile phases: methanol: ammonia (100:1.5, v:v), chloroform: acetone: ammonia (48.75: 48.75: 2.5, v:v:v), methanol: chloroform: ammonia (48.75: 48.75: 0.5, v:v:v) and glass plates precoated with silicagel 60 F254 (20x20) as a stationary phase were used. Densitometric scanning was performed at 263 nm. Two different extraction procedures have been applied: liquid-liquid extraction using dichloromethane at alkaline pH and solid-phase extraction using C18 cartridges.
Preliminary tests in order to establish the system of solvents for development, as well as the range of linearity, were conducted. The best separation of nicotine and cotinine was obtained by using methanol: chloroform: ammonia (48.75: 48.75: 0.5, v:v:v) as the mobile phase. The liquid-liquid extraction technique led to better results than solid phase extraction. The regression curves were linear (with a corresponding correlation coefficient higher than 0.99) in the quantities range of 200 ng–1000 ng/spot for both nicotine and cotinine. The UV spectra confirm the identification of nicotine and cotinine both in the standards and in the extracts after liquid-liquid extraction.
The proposed method can be applied for the simultaneous evaluation of nicotine and cotinine in biological samples at toxic/lethal levels. Thus, the method may be applicable in lethal nicotine intoxication cases in forensic toxicological analysis
Teeth’s roots management by means of periodontal surgery in combination with radicular odontoplasty
Catedra Stomatologie Terapeutică USMF „Nicolae Testimiţanu”The loss of the clinical crown, juxta or subgingival, is still a major problem of dentistry.
Most frequently this loss is of carious nature, simultaneously being the main reason of tooth
extraction. In this paper we’ll present a treatment in which the radicular rests will be used for the
future prosthetic restorations, which not that long were considered as indications for tooth
extraction.
Leziunile odontale coronare, totale sau subtotale, prezintă încă o problemă majoră a
stomatologiei. Cel mai frecvent leziunile odontale coronare sunt de natură carioasă – caria
simultan fiind şi principalul motiv de extracţie a dinţilor. În această lucrare vom prezenta un
tratament de păstrarea a resturilor radiculare pentru viitoarele restaurări protetice, care pînă nu
demult era considerat drept indicaţie pentru extracţia dentară
In vitro study of endodontic space of three molars
Rezumat.
Datorită complexităţii lor anatomo‑morfologice molarii trei sunt deseori
extraşi neajungându‑se la tratarea lor endodontică. Însă studierea detaliată
a particularităţilor anatomo‑clinice ne‑a ajutat să elaborăm o sistematizare
a complexului lor endodontic. Astfel s‑a depistat prevalenţa molarilor trei
cu 2 rădăcini la mandibulă şi a celor cu 3 rădăcini la maxilă, forma cea
mai des întâlnită la molarii trei mandibulari e dreaptă, iar la cei maxilari în
„C“, cu prevalenţa tipului I după Vertucci la ambele maxilare. Din rândul
canalelor principale cel mai frecvent se întîlnesc cele cu 3 canale, iar din
canalele secundare– anastomozele transverse. Comunicările intercanalare
au o incidenţă înaltă, atât la molarii mandibulari cât şi la cei maxilari, iar
cele mai numeroase canale laterale s‑au prezentat în treimea apicală (84%‑
la mandibulă şi 100% la maxilă).Summary.
Due to their anatomo‑morphological complexity third mollars are usually extracted not
being treated endodontically. Detailed study of
their anatomo‑clinical pecularities helped us to
systemize third mollars endodontic system. So
we found the prevalence of two rooted mandibular mollars and three roots in the maxillar ones. The most often root shape is straight
for mandibular teeth, and C‑shaped for the
maxillary ones, but on both jaws the most encountered class is type I Vertucci. Three main
canals are usually found, and transverse canals
are the secondary canals most frequent. Intercanal communications have a great incidence
on lower and upper jaw as well, but the most
lateral canals were presented in the apical
third(84%‑on mandible, 100%‑maxilla)
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