Concepts of modern quality systems in a manufacturing company

Universitatea de Stat de Medicină și Farmacie “Nicolae Testemițanu” din Republica MoldovaIntroducere. Industria farmaceutică este cea mai strict reglementată industrie din lume, în același timp aceasta face parte din top 10 industrii mondiale după volumul de producere și venit. Parțial, investițiile efectuate cu scopul de dezvoltare a tehnologiilor noi în industrie, sunt orientate către optimizarea procesului de fabricație, astfel majoritatea instrumentelor moderne utilizate în procesul de producere sau sinteză, sunt elaborate inițial cu atribute de susținere a calității de fabricație. Introducerea treptată a unor concepte noi în sistemul clasic de management al calității duce la optimizarea proceselor tehnologice prin eliminarea maximală a erorilor, facilitarea creării condițiilor corespunzătoare pentru fabricație, determinarea punctelor critice, elaborarea strategiilor de control, îmbunătățirea randamentului producerii și respectiv la creșterea valorică a întreprinderilor industriale.Introduction. Pharmaceutical industry is one of the most rigorously regulated industries in the world while being one of the top ten industries by the manufacturing volume and also by its revenue. Partially, the investments that are made with the purpose of developing new manufacturing technologies are targeted toward the optimization of manufacturing process and most of the modern instruments used in either drug manufacturing or the synthesis processes are initially formulated in order to be able to assist in ensuring the production quality. Gradual introduction of new concepts in the classic quality management system leads to optimization of technological processes by eliminating the errors, facilitating the establishment of the appropriate manufacturing conditions, determining the critical process parameters, drafting new control strategies, raising the production yield, rising this way the value of the manufacturing sites

Teeth whitening methods

Introduction: Facial appearance is part of human communication channels. Communication based on the aesthetic interest our intimate relationships, the family one, the social, professional or unprofessional. Therefore we can not ignore the growing importance that dental aesthetic has. In last few years whitening methods takes a leading place in treatment of tooth discoloration. The aim of this research is to study and apply in practice some teeth whitening methods. Material and methods: 35 patients in age from 18 to 37 were examined (33 women and 4 men with different tooth discolorations). In order to demonstrate the effectiveness of Opalescence whitening system, own clinical cases have been analyzed. Results: In all 4 groups of patients, whitening system “Opalescence” has presented good results. All patients had a decrease of tooth discoloration which was observed form the next visit. In 2 cases, patients have a temporary hypersensitivity to cold and warm, which was removed by applying gels like Flor Opal or Ultraeze (Ultradent). Patients have been instructed how to take care of their teeth in order to maintain newly acquired color. From prophylactic considerations, we recommended fluoride toothpaste “Sensodyne” and whitening toothpaste “Opalescence”. Results: Analysis of literature data shows that dentists now have multiple methods of treatment for tooth discoloration (veneers, bleaching), but these have to be applied according to the damage degree of dental tissues. Teeth whitening methods require patient monitoring and have to be performed in combination with remineralization therapy

Evalurea factorilor de risc asociaţi aderenţei la tratamentul DOTS Plus

Şcoala de Management în Sănătate Publică USMF „Nicolae Testemiţanu”This paper presents characteristics of multi-drug resistant tuberculosis (MDRTB) in the world, inclusively Moldova; data analysis and interpretation based on nominal data collection stored in the informational system of monitoring and evaluation of tuberculosis cases in Moldova (SIME TB). Data analysis and interpretation, evaluation of risk factors associated with adherence to treatment of patients with multi-drug resistant tuberculosis enrolled in DOTS Plus treatment in studied sample. Caracteristica tuberculozei multidrogrezistente în lume şi în Republica Moldova. Analiza şi interpretarea datelor în baza colectării informaţiei nominale stocată în sistemul informaţional de monitorizare şi evaluare a cazurilor de tuberculoză din Republica Moldova (SIME TB). Analiza şi interpretarea datelor, evaluarea factorilor de risc asociaţi aderenţei la tratament a pacienţilor cu tuberculoză multidrogrezistentă (MDR TB) înrolaţi în tratamentul DOTS Plus în baza eşantionului studiat

Tuberculosis in young population is a priority for public health

Şcoala de Management în Sănătate Publică USMF „Nicolae Testemiţanu”The description of the epidemiological situation regarding tuberculosis among 15 – 29 years old young, for the entire territory of Republic of Moldova for a period of 5 years (2004 to 2008). The analysis and interpretation of the data from the information stored in the nominal information monitoring and evaluation system of tuberculosis cases (SIME TB). Global morbidity predominantly affects segment of 20 - 29 years old – 81,3%. Alarming figures of multidrug resistant tuberculosis are observed among young new cases – 24,7%. Each day in the Republic of Moldova there are notified 3 new cases of active tuberculosis, one of them with bacillary form, the most dangerous form for the society. Descrierea situaţiei epidemiologice a tuberculozei în rîndul tinerilor de 15-29 ani pentru întreg teritoriul Republicii Moldova pe perioada de 5 ani (2004 - 2008). Analiza şi interpretarea datelor în baza colectării informaţiei nominale stocata în sistemul informaţional de monitorizare şi evaluare a cazurilor de tuberculoză (SIME TB). Preponderent morbiditatea globală afectează segmentul de vîrstă 20 – 29 ani în 81,3%. Cifre alarmante de tuberculoză multidrogrezistentă printre cazurile noi în rîndul tinerilor - 24,7%. Fiecare zi în Republica Moldova se notifica 3 cazuri noi de tuberculoză activă, dintre care unul cu forma bacilară, cea mai periculoasă formă pentru societate

Structure and form particularities of interradicular and interdental septa

Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: Interdental and interradicular septa represents anatomical structures that reference in different types of pathologies like: marginal periodontitis, paradontosis and dental migrations. In literature does not exist enough information about the structure and form varieties of interalveolar septa. We can mention next forms of septa: sharp lance form, dome form, crescent form and dissected form which is divided in: dissected properly and dissected in steps. All this types of forms have a different influence on pathological appearance on the bone structure. Another particularity is an cortical difference that may be not so pronounced at some persons, while to others it is more pronounced. Also a particularity is in the structure of cancellous bone where we can see the distance between bone trabeculae. By time in some pathological conditions we atest changes in interrdental and interradicular septa - thinning the cortical at septa's peaks, outbreaks of spongy bone tissue thinning etc. Purpose: Studying varieties of form and factors that influence their changes at interdental and interradicular septa's level in normal and pathological cases. Material and methods: Were studied 132 radiograms of patients that received medical help in USMF ,,Nicolae Testemitanu" dental clinic and in private dental clinic ,,Parodent Prim" SRL from Chisinau city. Radiographic clichés were analized at fluoroscopy. For study we used Новик И.О. classification.The method of collectioning the information was by selective method-were selected only radiograms that coresponded our classification criteria. Therewith we used the method of observation and analyze of types of interdental and interradicular septa in norm and pathological disease. Discussion results: Anatomical structures of interdental and interradicular septa are in strong relation with various factors: tooth anatomy of teeth and their position in the dental arch, type of vascularization, local physico-chemical conditions and local systemic factors. The interdental septum protrude at alveolar level and is more massive in relation with vestibular and oral alveolar wall. Interradicular septum are perfored by multiple holes, through which nervs and blood vessels pass. Cortical thickness is reduced at maxillary level than at mandibula. Normally the anatomical structure of septum is not standart, it has individual particularities (of shape, bone density). Analyzing the obtained data, we found that from 132 radiograms only 19 (14.39%) of cases was detected with normal structure interdental and interradiculare septa to young persons - 16-35 years. From this numbers, dome shaped septum -27,2 %; sharped lance- 25,3 %; halfmoon-46,72% and dissected shape-0,78%. Conclusion: 1. The analysis of data from speciality literature that confirms the four types of interdental septum: dome shaped, halfmoon, sharped lance and dissected shape. 2. The basic factors that influence the shape of septa are: the teeth anatomy and their position in arch, the functional ocluzal forces that are transmitted, type of vascularization, physico-chemical conditions of individual local and systemic factors. 3.Obtained results are in relationship with results from speciality literatury that refers to the form of septum: dome-27,2%; sharped lance- 25,3%; halfmoon-46,72% and dissected form- 0,78%. 4. Pathological condition mostly apears molars region where prevail the dome shaped septa

Current Concepts on Drug Abuse and Dependence

Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about the need for a greater precision in the definition. Drug dependence can be assigned not only to pharmacological effects of the drugs of abuse, but also to their interaction with each particular neurological and psychological constitution. The research on the neurobiological mechanisms of addiction processes allows both a better understanding of current pharmacotherapy and the development of new treatment strategies in drug abuse and dependence. In this review we intend to present the current concepts related to drug abuse and dependence

HPTLC assay of nicotine and cotinine in biological samples

This study presents the development of a simple high-performance thin layer chromatography (HPTLC) method for the determination of nicotine and its metabolite cotinine in human plasma and urine. The following mobile phases: methanol: ammonia (100:1.5, v:v), chloroform: acetone: ammonia (48.75: 48.75: 2.5, v:v:v), methanol: chloroform: ammonia (48.75: 48.75: 0.5, v:v:v) and glass plates precoated with silicagel 60 F254 (20x20) as a stationary phase were used. Densitometric scanning was performed at 263 nm. Two different extraction procedures have been applied: liquid-liquid extraction using dichloromethane at alkaline pH and solid-phase extraction using C18 cartridges. Preliminary tests in order to establish the system of solvents for development, as well as the range of linearity, were conducted. The best separation of nicotine and cotinine was obtained by using methanol: chloroform: ammonia (48.75: 48.75: 0.5, v:v:v) as the mobile phase. The liquid-liquid extraction technique led to better results than solid phase extraction. The regression curves were linear (with a corresponding correlation coefficient higher than 0.99) in the quantities range of 200 ng–1000 ng/spot for both nicotine and cotinine. The UV spectra confirm the identification of nicotine and cotinine both in the standards and in the extracts after liquid-liquid extraction. The proposed method can be applied for the simultaneous evaluation of nicotine and cotinine in biological samples at toxic/lethal levels. Thus, the method may be applicable in lethal nicotine intoxication cases in forensic toxicological analysis

Teeth’s roots management by means of periodontal surgery in combination with radicular odontoplasty

Catedra Stomatologie Terapeutică USMF „Nicolae Testimiţanu”The loss of the clinical crown, juxta or subgingival, is still a major problem of dentistry. Most frequently this loss is of carious nature, simultaneously being the main reason of tooth extraction. In this paper we’ll present a treatment in which the radicular rests will be used for the future prosthetic restorations, which not that long were considered as indications for tooth extraction. Leziunile odontale coronare, totale sau subtotale, prezintă încă o problemă majoră a stomatologiei. Cel mai frecvent leziunile odontale coronare sunt de natură carioasă – caria simultan fiind şi principalul motiv de extracţie a dinţilor. În această lucrare vom prezenta un tratament de păstrarea a resturilor radiculare pentru viitoarele restaurări protetice, care pînă nu demult era considerat drept indicaţie pentru extracţia dentară

In vitro study of endodontic space of three molars

Rezumat. Datorită complexităţii lor anatomo‑morfologice molarii trei sunt deseori extraşi neajungându‑se la tratarea lor endodontică. Însă studierea detaliată a particularităţilor anatomo‑clinice ne‑a ajutat să elaborăm o sistematizare a complexului lor endodontic. Astfel s‑a depistat prevalenţa molarilor trei cu 2 rădăcini la mandibulă şi a celor cu 3 rădăcini la maxilă, forma cea mai des întâlnită la molarii trei mandibulari e dreaptă, iar la cei maxilari în „C“, cu prevalenţa tipului I după Vertucci la ambele maxilare. Din rândul canalelor principale cel mai frecvent se întîlnesc cele cu 3 canale, iar din canalele secundare– anastomozele transverse. Comunicările intercanalare au o incidenţă înaltă, atât la molarii mandibulari cât şi la cei maxilari, iar cele mai numeroase canale laterale s‑au prezentat în treimea apicală (84%‑ la mandibulă şi 100% la maxilă).Summary. Due to their anatomo‑morphological complexity third mollars are usually extracted not being treated endodontically. Detailed study of their anatomo‑clinical pecularities helped us to systemize third mollars endodontic system. So we found the prevalence of two rooted mandibular mollars and three roots in the maxillar ones. The most often root shape is straight for mandibular teeth, and C‑shaped for the maxillary ones, but on both jaws the most encountered class is type I Vertucci. Three main canals are usually found, and transverse canals are the secondary canals most frequent. Intercanal communications have a great incidence on lower and upper jaw as well, but the most lateral canals were presented in the apical third(84%‑on mandible, 100%‑maxilla)