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    Use of therapeutic laser for prevention and treatment of oral mucositis

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    Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called "Mucositis Formula"). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/cmÂČ dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM.A mucosite oral (MO) afeta pacientes que sĂŁo submetidos ao transplante de cĂ©lulas-tronco hematopoĂ©ticas (TCTH) devido as altas doses de quimioterapia e/ou radioterapia. A proposta desta investigação foi realizar um estudo comparativo da freqĂŒĂȘncia e a evolução da MO entre os pacientes submetidos ao laser terapĂȘutico e da terapia convencional (uso de solução de bochecho chamada "FĂłrmula para Mucosite").Os pacientes foram submetidos ao regime de condicionamento mieloablativo antes da realização do TCTH alogĂȘnico.Vinte e dois pacientes foram selecionados e divididos em 2 grupos: grupo I foi irradiado com laser AlGaInP (660 nm) e laser GaAlAs (780 nm), potĂȘncia de 25 mW, dose de 6,3J/cmÂČ, tempo 10 s, seguido do tratamento convencional; grupo II submetido apenas ao tratamento convencional. Ambas as escalas da World Health Organization (WHO) e Oral Mucositis Assessment Scales (OMAS) foram utilizadas para avaliar os resultados. Os dados foram analizados pelo teste nĂŁo-paramĂ©trico de Wilcoxon, com p<0,05 considerado estatisticamente significante. O grupo I apresentou menor frequĂȘncia de MO (p=0,02) e menor mĂ©dia de acordo com as escalas WHO e OMAS (p<0,01 e p=0,01, respectivamente). Em conclusĂŁo, o laser reduziu a frequĂȘncia e gravidade da MO, sugerindo que o laser terapĂȘutico pode ser usado para ambos como uma nova forma de prevenção e tratamento da MO
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