Additional file 1: of Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis

Table S1. Spearman’s correlation coefficients among aeroallergens, Brussels-Capital Region, 2008–2013. Table S2. Confounding by air pollutants, influenza epidemics and general respiratory infections - Cumulative (lag 0–6 days) percentage change (95% confidence interval) in asthma hospitalizations associated with an interquartile range increase in pollen or fungal spore concentrations, Brussels-Capital Region, 2008–2013. Table S3. Sensitivity analyses - Cumulative (lag 0–6 days) percentage change (95% confidence interval) in asthma hospitalizations associated with an interquartile range increase in pollen or fungal spore concentrations, Brussels-Capital Region, 2008–2013. Figure S1. Cumulative (lag 0–6) exposure-response (ER) functions for the association between asthma admissions and some aeroallergen concentrations - Functions modelled using a natural cubic spline–natural cubic spline DLNM with 3 degrees of freedom (df) for the ER function and 4 df for the lag structure. Relative risks (RR) are relative to the reference value of 0 grains/m3. The vertical dotted lines represent the 75th, 95th and 99th percentiles of the pollen concentrations). (DOCX 37 kb

Silicone Wristband Passive Samplers Yield Highly Individualized Pesticide Residue Exposure Profiles

Monitoring human exposure to pesticides and pesticide residues (PRs) remains crucial for informing public health policies, despite strict regulation of plant protection product and biocide use. We used 72 low-cost silicone wristbands as noninvasive passive samplers to assess cumulative 5-day exposure of 30 individuals to polar PRs. Ethyl acetate extraction and LC-MS/MS analysis were used for the identification of PRs. Thirty-one PRs were detected of which 15 PRs (48%) were detected only in worn wristbands, not in environmental controls. The PRs included 16 fungicides (52%), 8 insecticides (26%), 2 herbicides (6%), 3 pesticide derivatives (10%), 1 insect repellent (3%), and 1 pesticide synergist (3%). Five detected pesticides were not approved for plant protection use in the EU. Smoking and dietary habits that favor vegetable consumption were associated with higher numbers and higher cumulative concentrations of PRs in wristbands. Wristbands featured unique PR combinations. Our results suggest both environment and diet contributed to PR exposure in our study group. Silicone wristbands could serve as sensitive passive samplers to screen population-wide cumulative dietary and environmental exposure to authorized, unauthorized and banned pesticides