A new type of lordosis and vertebral body compression in Gilthead seabream, Sparus aurata Linnaeus, 1758: aetiology, anatomy and consequences for survival

A new type of vertebral malformation is described, consisting of deformed cartilaginous neural and haemal processes and the compression and fusion of vertebral bodies. The malformation is designated as haemal vertebral compression and fusion (haemal VCF). We studied the aetiology of the malformations and described microanatomical histopathological alterations. The malformations were detected during routine quality control in one of six monitored Gilthead sea bream populations. Haemal VCF affected the posterior part of the vertebral column (haemal vertebrae). In 20% of the deformed specimens, haemal VCF was combined with lordosis. At 35dph (days post-hatching), early anatomical signs of the haemal VCF consisted of abnormal centrum mineralization, malformed cartilaginous neural and haemal processes and developing lordotic alterations. The histological examination of the deformed individuals revealed that haemal VCF is preceded by notochord abnormalities. The frequency of deformed individuals was three times higher at 35 than at 61dph (50.3% vs. 17.2%, n=157 and n=250, respectively). No signs of repair or reversion of malformations have been observed. Thus, the steep decrease in deformities in older animals suggests that haemal VCF is linked to high mortality rates. The results are discussed in respect of the possible causative factors of haemal VCF

Use Cases for Abnormal Behaviour Detection in Smart Homes

While people have many ideas about how a smart home should react to particular behaviours from their inhabitant, there seems to have been relatively little attempt to organise this systematically. In this paper, we attempt to rectify this in consideration of context awareness and novelty detection for a smart home that monitors its inhabitant for illness and unexpected behaviour. We do this through the concept of the Use Case, which is used in software engineering to specify the behaviour of a system. We describe a set of scenarios and the possible outputs that the smart home could give and introduce the SHMUC Repository of Smart Home Use Cases. Based on this, we can consider how probabilistic and logic-based reasoning systems would produce different capabilities

Decision makers\u27 experience of participatory dynamic simulation modelling: Methods for public health policy

Background: Systems science methods such as dynamic simulation modelling are well suited to address questions about public health policy as they consider the complexity, context and dynamic nature of system-wide behaviours. Advances in technology have led to increased accessibility and interest in systems methods to address complex health policy issues. However, the involvement of policy decision makers in health-related simulation model development has been lacking. Where end-users have been included, there has been limited examination of their experience of the participatory modelling process and their views about the utility of the findings. This paper reports the experience of end-user decision makers, including senior public health policy makers and health service providers, who participated in three participatory simulation modelling for health policy case studies (alcohol related harm, childhood obesity prevention, diabetes in pregnancy), and their perceptions of the value and efficacy of this method in an applied health sector context. Methods: Semi-structured interviews were conducted with end-user participants from three participatory simulation modelling case studies in Australian real-world policy settings. Interviewees were employees of government agencies with jurisdiction over policy and program decisions and were purposively selected to include perspectives at different stages of model development. Results: The ‘co-production’ aspect of the participatory approach was highly valued. It was reported as an essential component of building understanding of the modelling process, and thus trust in the model and its outputs as a decision-support tool. The unique benefits of simulation modelling included its capacity to explore interactions of risk factors and combined interventions, and the impact of scaling up interventions. Participants also valued simulating new interventions prior to implementation in the real world, and the comprehensive mapping of evidence and its gaps to prioritise future research. The participatory aspect of simulation modelling was time and resource intensive and therefore most suited to high priority complex topics with contested options for intervening. Conclusion: These findings highlight the value of a participatory approach to dynamic simulation modelling to support its utility in applied health policy settings

An Alternative Mission Paradigm for Healthy Church Growth

Christianity is becoming weaker and nominalized, and it is expected to be surpassed quantitatively by Islam in 2070. The purpose of this article is to analyze the limitations of the holistic mission paradigm, a representative view of mission today, in terms of healthy church growth, and to propose key points of an alternative mission paradigm which would be helpful for overcoming these limitations. The history of holistic mission is examined to show the identity and characteristics of the paradigm, and then an alternative mission paradigm that can contribute to healthy church growth is presented

An Alternative Mission Paradigm for Healthy Church Growth

Christianity is becoming weaker and nominalized, and it is expected to be surpassed quantitatively by Islam in 2070. The purpose of this article is to analyze the limitations of the holistic mission paradigm, a representative view of mission today, in terms of healthy church growth, and to propose key points of an alternative mission paradigm which would be helpful for overcoming these limitations. The history of holistic mission is examined to show the identity and characteristics of the paradigm, and then an alternative mission paradigm that can contribute to healthy church growth is presented

Comparing Neural Correlates of Visual Target Detection in Serial Visual Presentations Having Different Temporal Correlations

Most visual stimuli we experience on a day-to-day basis are continuous sequences, with spatial structure highly correlated in time. During rapid serial visual presentation (RSVP), this correlation is absent. Here we study how subjects' target detection responses, both behavioral and electrophysiological, differ between continuous serial visual sequences (CSVP), flashed serial visual presentation (FSVP) and RSVP. Behavioral results show longer reaction times for CSVP compared to the FSVP and RSVP conditions, as well as a difference in miss rate between RSVP and the other two conditions. Using mutual information, we measure electrophysiological differences in the electroencephalography (EEG) for these three conditions. We find two peaks in the mutual information between EEG and stimulus class (target vs. distractor), with the second peak occurring 30–40 ms earlier for the FSVP and RSVP conditions. In addition, we find differences in the persistence of the peak mutual information between FSVP and RSVP conditions. We further investigate these differences using a mutual information based functional connectivity analysis and find significant fronto-parietal functional coupling for RSVP and FSVP but no significant coupling for the CSVP condition. We discuss these findings within the context of attentional engagement, evidence accumulation and short-term visual memory

Exploring The Responsibilities Of Single-Inhabitant Smart Homes With Use Cases

DOI: 10.3233/AIS-2010-0076This paper makes a number of contributions to the field of requirements analysis for Smart Homes. It introduces Use Cases as a tool for exploring the responsibilities of Smart Homes and it proposes a modification of the conventional Use Case structure to suit the particular requirements of Smart Homes. It presents a taxonomy of Smart-Home-related Use Cases with seven categories. It draws on those Use Cases as raw material for developing questions and conclusions about the design of Smart Homes for single elderly inhabitants, and it introduces the SHMUC repository, a web-based repository of Use Cases related to Smart Homes that anyone can exploit and to which anyone may contribute

Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison

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Data Communication Between an Expert System Shell and a Conventional Algorithmic Program With Application to Cam Motion Specification

Although more and more expert system shells have begun to provide communication interfaces to conventional procedural languages, the interfaces are basically shell- and language-dependent. This paper presents a simple, shell- and language-independent data communication technique between a shell and a procedural language via a concept analogous to the handshake data transmission used in microprocessors. A control file is used for the action of handshake. The communication interface is between two data files in two different language environments. A program written in a LISP-based expert system shell, OPS 5, and one written in a procedural language, FORTRAN, were tested to verify the presented technique. An expert system for cam motion specification, which needs the following three tasks—symbolic representation, numerical computation, and their communication—is described as one of the possible applications of the technique. These three tasks are essential to automated engineering design and analysis