1 research outputs found
Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines
Type 1 phototherapeutic agents based on diarylamines
were assessed
for free radical generation and evaluated in vitro for cell death
efficacy in the U937 leukemia cancer cell line. All of the compounds
were found to produce copious free radicals upon photoexcitation with
UV-A and/or UV–B light, as determined by electron spin resonance
(ESR) spectroscopy. Among the diarylamines, the most potent compounds
were acridan (<b>4</b>) and 9-phenylacridan (<b>5</b>),
with IC<sub>50</sub> values of 0.68 μM and 0.17 μM, respectively