Effects of aqueous extracts of <i>Acacia albida</i> stem bark on Wistar albino rats infected with <i>Trypanosoma evansi</i>

<div><p>The effect of aqueous extract of <i>Acacia albida</i> stem bark was investigated in Wistar albino rats infected with <i>Trypanosoma evansi</i>. The extract showed highest reduction in parasitemia at the dose of 600 mg/kg body weight (bw). A dose of 300 mg/kg bw improved packed cell volume the most by 14.35%. The group treated with 150 and 600 mg/kg bw of the extract showed significant decrease (<i>P</i> < 0.05) in alanine transaminase and aspartate transaminase levels which were lower than those of the group treated with diminazene aceturate. The group treated with 150 mg/kg bw of the extract showed the least urea, albumin and protein level and lowest relative organ weight. There was a significant difference (<i>P</i> < 0.05) in the levels of catalase and Thiobarbituric acid reactive substances in liver and kidney of the animals in the infected-untreated group and the extracts-treated groups. The results of this study show that the extracts of <i>A. albida</i> have antitrypanosomal activity against <i>T. evansi</i> infection.</p></div