1 research outputs found
A Convergent Continuous Multistep Process for the Preparation of C<sub>4</sub>‑Oxime-Substituted Thiazoles
We
report a strategy designed for the rapid and convergent assembly
of C<sub>4</sub>-oxime substituted thiazoles. Our approach relied
on 3-bromo-2-oxopropanal <i>O</i>-methyl oxime <b>7</b> as a key building block. A three-step sequence to <b>7</b> was designed, which, for safety concerns, could only be operated
in batch mode on limited scales (≪100 g). We describe herein
how we addressed such a limitation, by designing a multistep continuous
synthesis of this intermediate and further demonstrate the advantages
of flow reactor configuration upon scaling up