33 research outputs found
Synthesis and characterization of transition metal complexes derived from some biologically active furoic acid hydrazones
Two new physiologically active ligands, N’-2-[(E)-1-hydroxy-4-methyl-2-oxo-2H-8-chromenyl) ethylidene)-2-furan carbohydrazide (HMCFCH) and N’-2-[(Z)-1-(4-hydroxy-6-methyl-2-oxo-2H-pyranyl) ethylidene]-furan carbohydrazide (HMPFCH) and their VO(II), Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) complexes have been prepared. The ligands and the metal complexes have been characterized by elemental analyses, electrical conductance, magnetic susceptibility measurements, UV-Vis, IR, and ESR spectroscopic data. Basing on the above data, Fe(II) and Co(II) complexes of HMCFCH and HMPFCH have been assigned a dimeric octahedral geometry. VO(II) complexes of HMCFCH and HMPFCH have been assigned sulfate bridged dimeric square pyramidal geometry. Mn(II) complex of HMCFCH has been assigned a dimeric octahedral geometry, where as Mn(II) complex of HMPFCH has been ascribed to monomeric octahedral geometry. Cu(II) and Ni(II) complexes of HMCFCH have been ascribed to a polymeric structure. Ni(II) complex of HMPFCH has been assigned a dimeric square planar geometry. Cu(II) complex of HMPFCH has been proposed an octahedral geometry. The ligands and their metal chelates were screened against S. aureus and P. aeruginosa. The ligands and the metal complexes have been found to be active against these microorganisms. The ligands show more activity than the metal complexes. KEY WORDS: N’-2-(E)-1-hydroxy-4-methyl-2-oxo-2H-8-chromenyl) ethylidene)-2-furan carbohydrazide (HMCFCH), N’-2-[(Z)-1-(4-hydroxy-6-methyl-2-oxo-2H-pyranyl) ethylidene]-furan carbohydrazide (HMPFCH), 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione, 8-Acetyl-4-methyl-Umbelliferone, Furoic acid hydrazide, Anti microbial activity  Bull. Chem. Soc. Ethiop. 2007, 21(1), 63-73.
Pseudotumoral Malacoplakia of the Bladder
Malacoplakia is a rare inflammatory condition most often affecting the genitourinary system. We report the case of a 24-year-old man who presented with gross hematuria, nocturia, frequency, dysuria and considerable weight loss during the preceding three months. Digital rectal examinationshowed a solid pelvic mass. Ultrasonography and computed tomography showed calyceal dilatation on the right side and a solid bladder mass 10 cm in diameter suspicious of bladder cancer. Transurethral resection of the tumor was incomplete, due to the large volume of the bladder mass. Histological examination of the resected specimen revealed malacoplakia of the bladder. The patient was treated with fluoroquinolone and vitamin C. Follow-up at 3 months showed marked regression of the bladder mass and complete resolution of the calyceal dilatation
Métastases péniennes après cystoprostatectomie pour carcinome urothélial de la vessie
L’apparition de métastases péniennes dans l’évolution du carcinome urothélial est un événement rare (1 à 8%). Elles surviennent le plus souvent (65%) dans les 18 mois suivant le diagnostic de la lésion primaire et leur pronostic est sombre avec une survie dépassant exceptionnellement 20 mois. Le traitement des métastases caverneuses est multidisciplinaire. Les meilleurs résultats en termes de survie globale ont été obtenus avec l’association amputation de la verge associée à une chimiothérapie. Les auteurs rapportent un cas de métastases développées aux dépens des corps caverneux de la verge après cystoprostatectomie pour carcinome urothélial de la vessie et discutent les problèmes diagnostics, thérapeutiques et pronostiques que pose cette localisation secondaireMots clés : Carcinome urothélial, métastases, corps caverneux, traitement, pronosti
Adénome de prostate révélé par des hypoglycémies profondes: A propos d'un cas
RésuméIntroductionEnviron 90% des patients diabétiques présentent un diabète de type 2. L'hypoglycémie constitue le principal effet indésirable des antidiabétiques oraux. Elle est d'autant plus grave qu'elle s'accompagne d'une insuffisance rénale.Cas cliniqueNous rapportons le cas d'un homme âgé de 85ans suivi pour un diabète de type 2 et une hypertension artérielle. Il a été admis via les urgences dans un tableau de trouble de conscience associé à une fièvre. Le bilan réalisé a objectivé une hypoglycémie profonde, une insuffisance rénale obstructive et un taux de PSA élevé (antigène spécifique de la prostate). Les antidiabétiques oraux ont été arrêtés et un sondage vésical a été effectué avec comme résultats une correction des hypoglycémies et de la fonction rénale. Le patient a eu une résection trans-urétrale de la prostate (RTUP) et l'examen anatomopathologique était en faveur d'un adéno-myo-fibrome. Les troubles neurologiques en rapport avec l'hypoglycémie étaient sous forme d'agitations, délire, trouble des fonctions supérieures et troubles du sommeil. Cependant notre patient n'a pas présenté de déficit neurologique. L’évolution clinique était favorable.ConclusionL'insuffisance rénale obstructive peut constituer une complication de l'adénome de la prostate à un stade ultime. Elle est responsable d'accumulation dans le sang de médicaments y compris les antidiabétiques oraux. L'hypoglycémie qui en résulte est délétère pour la qualité de vie du patient et peut être responsable d'accidents neurologiques.AbstractIntroductionApproximately 90% of patients with diabetes have type 2 diabetes. Hypoglycemia is the main side effect of oral antidiabetics, and it can be more serious when it is accompanied by renal failure.Clinical caseWe report the case of a man aged 85 years followed for type 2 diabetes and hypertension. He was admitted via the emergency with a disturbed level of consciousness associated with fever. The medical evaluation revealed profound hypoglycemia, obstructive renal failure and an elevated PSA (prostate specific antigen). Oral hypoglycemic agents were discontinued and catheterization was performed resulting in correction of hypoglycemia and renal function. The patient underwent a transurethral resection of prostate (TURP) and pathologic examination was in favor of benign hyperplasia. Neurological disorders related to hypoglycemia were agitation, delirium, impaired higher functions and sleep disorders. However our patient did not present any neurological deficit. The clinical course was favorable.ConclusionThe obstructive renal failure can be a complication of benign prostatic hyperplasia in a final stage. It is responsible for accumulation in the blood of drugs including oral anti-diabetic agents. The resulting hypoglycemia is deleterious to the quality of life of the patient and may be responsible for neurological disorders
La chirurgie conservatrice dans le cancer du rein
Le cancer du rein représente 3% des cancers. Il est classé au troisième rang des cancers urologiques après celui de la prostate et de la vessie. Depuis la néphrectomie totale élargie de Robson en 1963, on assiste à un changement continu de la prise en charge de ce cancer. En 1990, on a mis en question le curage ganglionnaire systématique. En 1993, on a mis en question la surrénalectomie systématique. En 1995, on a commencé à proposer la chirurgie conservatrice pour les tumeurs dont le diamètre est inférieur à 4 cm. A partir de 2004, on l’a proposée pour les tumeurs < 7 cm. En fonction de la taille et de la localisation tumorale, on peut réaliser une néphrectomie partielle polaire, une résection cunéiforme, une énucléation, une chirurgie ex situ ou zéro ischémie. L’ischémie froide permet une meilleure conservation de la fonction rénale, ainsi que le clampage parenchymateux par rapport au clampage pédiculaire. La chirurgie conservatrice du cancer du rein est en nette progression certes, mais elle n’a pas encore la place qu’elle mérite. Ceci peut être lié à une méconnaissance des indications, ou crainte des morbidités. La limite arbitraire de 7 cm mérite d’être discutée. L’évolution naturelle se fait vers la chirurgie conservatrice quelque soit la taille de la tumeur et quelque soit le rein controlatéral, à condition qu’elle soit techniquement réalisable.Mots Cles: Cancer rénal; chirurgie conservatrice; clampage; ischémie froide
Climate Change and Maize Production: Empirical Evidence from Kaduna State, Nigeria
An estimated 80% of the maize crop suffers periodic yield reduction due to drought stress. Drought at flowering and grain filling period may cause losses of 40-90%. Predicated on the argument that climate change resulted from changes in climatic elements such as rainfall, this study aimed at investigating the relationship between rainfall, among other factors, and maize crop production in Kaduna state over a period of 15 years. Time series data on aggregate maize production, fertilizer use, total area under cultivation with the maize crop and annual rainfall in Kaduna State for the period 1990-2005 were collected and analysed using multiple regression technique. Findings of the study showed that annual rainfall contributes significantly and positively to maize production in the study area inspite of climate change, indicating that climate change has not significantly altered the pattern of rainfall in the study area in such a way as to affect maize production negatively
Climate Change and Maize Production: Empirical Evidence from Kaduna State, Nigeria
An estimated 80% of the maize crop suffers periodic yield reduction due to drought stress. Drought at flowering and grain filling period may cause losses of 40-90%. Predicated on the argument that climate change resulted from changes in climatic elements such as rainfall, this study aimed at investigating the relationship between rainfall, among other factors, and maize crop production in Kaduna state over a period of 15 years. Time series data on aggregate maize production, fertilizer use, total area under cultivation with the maize crop and annual rainfall in Kaduna State for the period 1990-2005 were collected and analysed using multiple regression technique. Findings of the study showed that annual rainfall contributes significantly and positively to maize production in the study area inspite of climate change, indicating that climate change has not significantly altered the pattern of rainfall in the study area in such a way as to affect maize production negatively
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Drainage percutané de l’abcès du psoas: Notre expérience et revue de la littérature. Percutaneous drainage of psoas abscess. Our experience and literature review
Introduction: L’abcès du muscle psoas, infection rétropéritonéale rare et de diagnostic difficile, affecte, des sujets débilités. Le but de notre étude était de rapporter notre expérience du drainage percutané, peu invasive, dans le traitement de cette affection.
Patients et méthodes: Nous rapportons, de façon rétrospective une série de 22 patients suivis au, service d’urologie de l’hôpital militaire Moulay Ismaïl de Meknès (Maroc) sur une période de sept ans, allant de Janvier 2005 et Janvier 2012. Tous les patients avaient eu un drainage percutané de l’abcès, sous guidage échographique ou tomodensitométrique. Une antibiothérapie adaptée était associée au, traitement chirurgical.
Résultats: Tous les patients avaient une altération de l’état général, 10 (45%) étaient diabétiques., L’évolution postopératoire était constamment favorable. Une récidive de l’abcès a été notée chez deux, patients (9%) traitée favorablement par drainage percutané. Les caractéristiques diagnostiques, cliniques, biologiques et radiologiques de l’affection sont décrites.
Conclusion: Le drainage percutané est une technique facile et fiable. Peu invasive, et pouvant être, répétée en cas de nécessité, elle convient aux patients généralement débilités