Fourth Derivative and Compensated Area under the Curve Spectrophotometric Methods Used for Analysis Meloxicam in the Local Market Tablet

Two Rapid, direct, ecological friendly and economical spectrophotometric methods were used for estimation of meloxicam in the market Tablet dosage form. The First method is based on the use the fourth order derivative spectrum (D4) and the second method is depend-ed on the ratio of the area under the curve for the two peaks in the drug (Compensated area under the curve). The linear calibration graphs of the two methods were measured in the con-centration range (5-35)mg/l and the average of recoveries for local market Tablet (AWA)® were 99.8% for D4 method and 100.2% for CAUC method which indicating a good accuracy and precision for these methods. In this study, the results obtained by these suggested meth-ods have been successfully statistically compared by t-test and Mann-Whitney test showed a good agreement

Synthesis, Characterization and Anti Microbial Activity of Some New Derivatives Containing Imidazol Moiety

This paper involves synthesis some new imidazol derivatives were synthesized reaction of p-nitro Aniline with 3-chloro 2,4-pentadione with KSCN to give [1-(4-Nitro Phenyl)-2-Mercapto-4-methyl-1H-imidazol-5-yl)]-ethanone(1). Which reaction with different aromatic aldehydes according to claisen. Schmidt condensation to get a chalcones were reacted with hydrazine Hydrate to obtained the pyrazol derivatives and (4a-c) was synthesized by the treatment of pyrazol derivatives with benzoyl chloride in TEA. The chalcones were cyclized with the hydroxyl amine hydro chloride to give an iso oxazole derivatives which condensed with furan-2-aldehyde to obtain compounds(6a-c). These compounds  were characterized using FTIR and  1H-NMR. Anti microbial study in  vitro screened against several bacterial by cup plate agar diffusion method and also very good antibacterial activity  was observe