Teneligliptin add on to monotherapy treatment in patients with type 2 diabetes

Background: In patient with type 2 diabetes (T2D) inadequately controlled on monotherapy, teneligliptin is efficacious and safe as add-on to treatment with oral antidiabetic drugs (OADs) or insulin. Data on efficacy of teneligliptin in Indian patients is relatively sparse. Aim of the study was to assess the efficacy of teneligliptin used as add-on treatment in patients inadequately controlled on monotherapy with OADs or insulin.Methods: We retrospectively evaluated the electronic database at our endocrinology clinic from East India. Patients who were treated with teneligliptin (20 mg/day) as add-on to monotherapy with OADs or insulin were identified, and data analysed. Primary assessment parameters were change in glycosylated haemoglobin (HbA1c %), fasting plasma glucose (FPG, mg/dL) and post-prandial plasma glucose (PPG, mg/dL) over 12-week from the addition of teneligliptin. Paired t test and McNemar test applied to derive statistical significance of paired continuous and categorical variables respectively.Results: In 88 patients, teneligliptin was used as add-on treatment in 77.3% and 22.7% patients receiving OAD and insulin as monotherapy respectively. Mean age of population was 48.3±15.1 years and 67% were males. From baseline to 12-weeks, there was significant change in HbA1c (9.6±2.1 to 8.4±1.2%, P<0.001), FPG (181.4±54.5 to 140.9±27.1 mg/dL, P<0.001) and PPG (273.7±75.6 to 201.1±47.7 mg/dL, P<0.001). Reduction in these glycemic parameters was significant in patients with teneligliptin as add-on to either OADs or insulin. Overall, 12.5% patients reached the target HbA1c of <7% after 12-week treatment (P=0.004).Conclusions: In patients who are uncontrolled on monotherapy with either OADs or insulin, addition of teneligliptin resulted in significant reduction of HbA1c, FPG and PPG after 12-week treatment. This establishes usefulness of teneligliptin in Indian patients with T2D. A larger, randomized, comparative study with other gliptins is warranted

Coding Estimation based on Rate Distortion Control of H.264 Encoded Videos for Low Latency Applications

In the field of video processing, advancements in video compression at various temporal and spatial resolutions which are needed in our research to quantify estimation of video quality whereabouts within spatial and temporal domain itself. It was necessary in our research to study the impacts of related video coding conditions upon perceptual quality due to issue raised by User Experience community regarding poor coding. But most of research studies are concerned with coding distortions affected by mostly due to poor coding which address high spatio-temporal resolutions. This paper presents overall 120 test scenarios for video sequences having low spatial and temporal spectral information were studied. Finally we concluded that even after achieving consistency within subjective scores, we got relevant data consistency after refining subjective scores, so it is not poor coding its due channel capacity which was traced out by rate distortion control

Investigation of surface integrity, material removal rate and wire wear ratio for WEDM of Nimonic 80A alloy using GRA and Taguchi method

AbstractThis paper presents the investigation on surface integrity, material removal rate and wire wear ratio of Nimonic 80A using WEDM process. Taguchi's design of experiments methodology has been used for planning and designing the experiments. All of the input parameters and two factors interactions have been found to be statically significant for their effects on the response of interest. SEM was performed on the machined samples to investigate the effect and microstructure of the samples after machining. A higher pulse-on time setting leads to thicker recast layer. At lower value of pulse-on time and higher value of pulse-off time, the wire deposition on the machined surface is low

Dump slope stability analysis

In this modern world mining has become an integral part of our life. Mining activities effect in generation of both economic and noneconomic materials. The noneconomic materials are stored at selected places known as waste dumps. The stability of the waste dump has been of a matter of great concern over the years. The problems increases with limiting availability of land. In this project work the slope stability analysis is carried out for the waste dump of a selected iron ore open cast mine. In this process samples are collected and tests are carried out on these samples to get different geotechnical parameters. The factor of safety of different sections of the existing design of the selected mine are calculated by the help of GALENA software. In the end new design of dump slope are proposed by optimising the bench dimensions and material properties by the help of back analysis of GALENA. Then conclusion and various recommendation are given on the basis of new design of the dump slope

A case of pleural neurofibroma: A rare pleural tumor

Neurofibromas (NFs) are benign tumors involving any nerve from the root level to the smallest branch. They may enlarge locally and cause a pressure effect on thoracic structures such as trachea, superior vena cava, and esophagus. Pulmonary and pleural involvement is very rarely seen. We have reported a case of a pleural effusion secondary to lymphatic obstruction due to remnant NF for which patient had undergone surgical resection in the past

New optical telescope projects at Devasthal Observatory

Devasthal, located in the Kumaun region of Himalayas is emerging as one of the best optical astronomy site in the continent. The minimum recorded ground level atmospheric seeing at the site is 0.6 arcsec with median value at 1.1 arcsec. Currently, a 1.3-m fast (f/4) wide field-of-view (66 arcmin) optical telescope is operating at the site. In near future, a 4-m liquid mirror telescope in collaboration with Belgium and Canada, and a 3.6-m optical telescope in collaboration with Belgium are expected to be installed in 2013. The telescopes will be operated by Aryabhatta Research Institute of Observational Sciences. The first instruments on the 3.6-m telescope will be in-house designed and assembled faint object spectrograph and camera. The second generation instruments will be including a large field-of-view optical imager, high resolution optical spectrograph, integral field unit and an optical near-infrared spectrograph. The 1.3-m telescope is primarily used for wide field photometry imaging while the liquid mirror telescope will see a time bound operation to image half a degree wide strip in the galactic plane. There will be an aluminizing plant at the site to coat mirrors of sizes up to 3.7 m. The Devasthal Observatory and its geographical importance in between major astronomical observatories makes it important for time critical observations requiring continuous monitoring of variable and transient objects from ground based observatories. The site characteristics, its expansions plans and first results from the existing telescope are presented.Comment: Invited paper, 12 pages, SPIE Conference, July 201