Secure Mutual Testing Strategy for Cryptographic SoCs

This article presents a secure mutual testing strategy for System-on-Chips (SoCs) that implement cryptographic functionalities. Such approach eliminates the need for an additional trusted component that is used to test security sensitive cores in a SoC, like symmetric and public-key cryptographic modules. We combine two test approaches: Logic Built In Self Test (BIST) and secure scan-chain based testing and develop a strategy that preserves the test quality of the standard test methods, enhancing security of the testing scheme. In order to minimize the area overhead of the presented solution, we re-use the existing modules in different manners: a public-key cryptographic core to build the BIST infrastructure and a symmetric one to authenticate a device under test to a test server, thus preventing an unauthorized user from accessing the test interface. By doing so, we achieve both testability and security at the minimal cost

Role of modifying genes on the severity of rare mutation of MYH7 gene in hypertrophic obstructive cardiomyopathy

Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder due to mutations in sacromeric genes with variable penetrance. Hypertrophic Obstructive Cardiomyopathy (HOCM) is a major complication of Hypertrophic Cardiomyopathy. Unexplained hypertrophy in the Left Ventricle (LV) or Intraventricular Septum (IVS) had been the diagnostic criterion for HCM which is more often confirmed by the echocardiography. The frequency of HCM in general population is 1:500 and about 60-70% genetic predisposition is known. It has been observed that mutations in the Cardiac myosin binding proteinC (MYBPC3) gene causes late onset of disease with mild symptoms while mutations in the Beta Myosin Heavy chain (MYH7) gene leads to early onset with severe symptoms. Apart from Epigenetic and Environmental factors, modifier genes further complicate the situation leading to altered clinical outcome even among the same family members having identical mutation

Effect of BMI on maximum oxygen uptake of high risk individuals in a population of eastern Uttar Pradesh

Background: Herein, we report the effect of body mass index (BMI) on respiratory fitness by measuring maximum oxygen uptake after a short-term aerobic exercise. 20-40 years old healthy male individuals were divided into three categories according to their BMI and asked to perform aerobic exercise on a treadmill. Maximum oxygen uptake (VO2max) immediately after the exercise was recorded and statistically analyzed. Materials and methods: Thirty individuals of age within the range of 20-40 years were first medically examined to be certain that they did not have any cardiorespiratory complications and their BMI was calculated. Based on their BMI, they were classified into three—normal, overweight and obese groups and subjected to a treadmill exercise as per Bruce Protocol. Recorded data were analyzed and student t-test was performed to test significance of the data. Result: It was observed that the VO2max decreases as BMI increases. Conclusion:  This study establishes a correlation between maximum oxygen uptake and BMI of individuals that suggests that with increased BMI, VO2max decreases resulting into a decrease in respiratory fitness level. This trend was found to be consistent among all normal, overweight and obese group individuals. There are numerous reports on respiratory endurance where individuals were subjected to aerobic exercises over a long period of time. Here, we have studied the immediate effect of an aerobic exercise on the maximum oxygen uptake of normal and high risk individuals who were not subjected to long term exercises for respiratory endurance

On the Implementation of Unified Arithmetic on Binary Huff Curves

Unified formula for computing elliptic curve point addition and doubling are considered to be resistant against simple power-analysis attack. A new elliptic curve formula known as unified binary Huff curve in this regard has appeared into the literature in 2011. This paper is devoted to analyzing the applicability of this elliptic curve in practice. Our paper has two contributions.We provide an efficient implementation of the unified Huff formula in projective coordinates on FPGA. Secondly, we point out its side-channel vulnerability and show the results of an actual attack. It is claimed that the formula is unified and there will be no power consumption difference when computing point addition and point doubling operations, observable with simple power analysis (SPA). In this paper, we contradict their claim showing actual SPA results on a FPGA platform and propose a modified arithmetic and its suitable implementation technique to overcome the vulnerability

Effects on pregnancy in mice of passive immunization against ovine LH and human chorionic gonadotrophin

Mice given daily i.p. injections of immunoglobulins against ovine LH on Days 3-7 of pregnancy were devoid of implantation sites on Day 8 whereas mice treated with antibodies to hCG had embryos of normal number and appearance on Day 8. These antibody treatments reduced the mean ± s.d. serum progesterone concentrations from 65.4 ± 15.3 ng/ml (control globulins) to 8.6 ± 4.9 ng/ml (anti-LH) and 9.2 ± 3.1 ng/ml (anti-hCG) on Day 8 and had no differential effect on serum oestrogen levels on Day 4. However, the mice treated with anti-hCG did not litter; resorption of the embryos took place between Days 10 and 14 of pregnancy. Indirect immunofluorescence and quantitative immunoenzymic assays showed the presence of anti-ovine LH and anti-hCG reacting antigens in the mouse feto-placental unit. On Day 6, the values of reacting antigens (mean ± s.d. absorbance units/10 µm section of embryo) were 0.050 ± 0.002 with control globulins, 0.059 ± 0.002 with anti-hCG-Ig and 0.196 ± 0.018 with anti-LH-Ig; the corresponding values on Day 12 were 0.075 ± 0.009, 0.402 ± 0.02 and 0.416 ± 0.015. The quantitative disposition of the reacting antigens to the two types of anti-gonadotrophins seems to bear a temporal relationship to their respective antifertility action. The pregnancy terminating action of immunoglobulins to ovine LH (Days 6, 7 & 8) and hCG (Days 8, 9 & 10) was counteracted by administration of 2 mg medroxyprogesterone acetate on Days 6, 9 and 12, indicating the importance of progesterone in the maintenance of pregnancy in the mouse

Prevalence, Response to Cysticidal Therapy, and Risk Factors for Persistent Seizure in Indian Children with Neurocysticercosis

Background. Neurocysticercosis (NCC) is the commonest cause of childhood acquired epilepsy in developing countries. The use of cysticidal therapy in NCC, except “single lesion NCC,” is still debated in view of its doubtful usefulness and potential adverse effects. Methods. Children presenting with first episode of seizure or acute focal neurological deficit without fever were screened for NCC and received appropriate therapy (followup done for 1 year to look for the response and side effects). Results. The prevalence of NCC was 4.5%. Most common presenting feature was generalized seizure and commonest imaging finding was single small enhancing lesion in the parietal lobe. Abnormal EEG and CSF abnormalities were found in almost half of the children. The response to therapy was very good with infrequent recurrence of seizure and adverse effects of therapy were encountered rarely. No risk factors for persistent seizure could be identified. Conclusion. Present study shows that the response to cysticidal therapy is very good in NCC as seizure recurrence was observed in only 5%, 4.2%, and 4.2% of cases at 3-month, 6-month, and 1-year followup. Adverse effects of therapy were observed in 20% of cases during therapy but they were mild and self-limiting