2 research outputs found
Recyclable Thermosets Based on Dynamic Amidation and Aza-Michael Addition Chemistry
Utilizing
the dynamic amidation and aza-Michael addition chemistry, a set of
high strength, recyclable, and self-healable covalent adaptable networks
(CANs) are synthesized by reacting the precursor and commercial oligoamine
cross-linkers under mild temperature (25–50 °C) and solvent-free
conditions. The amide linkages present in these CANs are readily hydrolyzable
under mild acidic (pH = 5.3) conditions, whereas the aza-Michael adducts
with secondary amines are thermally reversible. Utilizing the above,
these CANs are depolymerized under ambient conditions in mild acidic
solution and recycled with retention of original mechanical properties.
The crack on the material surface is self-healed at 50 °C. The
precursor, a Knoevenagel condensation product of terephthalaldehyde
and diethyl malonate, is easily synthesized in a large scale. Suitable
model compounds are synthesized and studied to further understand
the transformations involved in the polymerization–depolymerization
of these networks. These networks exhibit adequate tensile properties
(ultimate tensile strength ≤35 MPa and Young’s modulus
≤3 GPa), and the properties can be tuned further by suitably
changing the oligoamine cross-linker. The simplicity of synthesis,
cost effectiveness, adequate mechanical property, stability in aqueous
and organic media, and recyclability along with self-healability render
these CANs suitable for a range of applications
Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from <i>Vitex negundo</i>
The compound 2,3-dehydrosilychristin, a flavonolignan linked to silychristin and silymarin, remains intriguing due to its challenging isolation from silymarin. While silymarin has been the exclusive source of flavonolignans – silybin, silychristin and silydianin − 2,3-dehydrosilychristin is reported in this study from Vitex negundo Linn. leaves. 2,3-Dehydrosilychristin (7) and 14 other compounds were isolated through focused extraction. Its subsequent pharmacological evaluation demonstrated potent antioxidant and in-vitro anti-inflammatory effects, notably inhibiting cytokines TNF-α, IL-6, IL-8 and VEGF. In in-vivo assessments, 2,3-dehydrosilychristin (7) revealed remarkable hepatoprotective potential by reducing liver enzyme levels AST and ALT. These findings expand the potential of 2,3-dehydrosilychristin and suggest bioprospecting Vitex species as alternate sources of bioactive flavonolignans.</p