1 research outputs found
Bioinspired Nanotheranostic Agents: Synthesis, Surface Functionalization, and Antioxidant Potential
Bioinspired synthesis of nanomaterials
is highly advantageous as
a natural and cost-effective resource. Development of noble metal
nanotheranostic agents was achieved through bioinspired synthetic
routes. These biosynthesized nanoparticles were characterized by various
analytical techniques including absorption spectroscopy, FTIR and
electron microscopy (SEM and TEM). A large number of medicinal plants
were screened, among which <i>Potentilla fulgens</i> (PF,
vajradanti) and <i>Camellia sinensis</i> (CS, green tea)
were found to produce nanomaterials with higher yields. Plant (PF
and CS) mediated metallic nanoparticles had added advantage of metal
reduction and simultaneous phytochemical capping over chemically synthesized
procedures, which require multiple reagents. Antioxidant potential
of the nanomaterials was determined by in vitro antioxidant assays
confirming substantial antioxidant properties, which was due to the
presence of phytochemicals on the nanoparticle surface. Flavonoids
and catechins on the nanomaterial surface served as the supplier of
hydroxyl groups for further derivatization. The surface of the nanoparticles
was engineered by conjugating imaging and therapeutic moieties, resulting
in the formation of theranostic nanoagents. The multimodal agents
were characterized and the extent of drug loading was determined to
validate the efficacy of those nanoconjugates. These bioinspired multimodal
nanoprobes can serve as essential diagnostic and therapeutic tools
in ongoing biomedical research