Jeune syndrome: description of 13 cases and a proposal for follow-up protocol

Jeune syndrome (asphyxiating thoracic dystrophy, ATD) is a rare autosomal recessive skeletal dysplasia characterized by a small, narrow chest and variable limb shortness with a considerable neonatal mortality as a result of respiratory distress. Renal, hepatic, pancreatic and ocular complications may occur later in life. We describe 13 cases with ages ranging from 9 months to 22 years. Most patients experienced respiratory problems in the first years of their life, three died, one experienced renal complications, and one had hepatic problems. With age, the thoracic malformation tends to become less pronounced and the respiratory problems decrease. The prognosis of ATD seems better than described in literature and in our opinion this justifies long term intensive treatment in the first years. We also propose a follow-up protocol for patients with ATD

Tourisme et souci de l'autre. En hommage à Georges Cazes

Collection : Tourisme et sociétésGeorges Cazes oeuvre décisivement pour que le tourisme soit pris en compte comme domaine d'enseignement et de recherche. Il a ouvert la voie à un débat sur les liens entre le tourisme et le développement, en respectant les réalités sociologiques des pays étudiés. Loin de conduire une sorte de néocolonialisme théorique et scientifique, il a toujours respecté le principe suivant : "les volontés locales avant la demande touristique". Il plaide aujourd'hui pour l'éclosion d'une véritable "géographie du désir"

Tourisme et souci de l'autre. En hommage à Georges Cazes

Collection : Tourisme et sociétésGeorges Cazes oeuvre décisivement pour que le tourisme soit pris en compte comme domaine d'enseignement et de recherche. Il a ouvert la voie à un débat sur les liens entre le tourisme et le développement, en respectant les réalités sociologiques des pays étudiés. Loin de conduire une sorte de néocolonialisme théorique et scientifique, il a toujours respecté le principe suivant : "les volontés locales avant la demande touristique". Il plaide aujourd'hui pour l'éclosion d'une véritable "géographie du désir"

Effects of Juglans regia Root Bark Extract on Platelet Aggregation, Bleeding Time, and Plasmatic Coagulation: In Vitro and Ex Vivo Experiments

Platelets have an important role in thrombosis and haemostasis. Hyperactivity of the platelets has been associated with thromboembolic diseases and represents the main cause of complications of cardiovascular diseases. Crude aqueous extract (CAE) of Juglans regia root bark was evaluated for bleeding time, antiaggregant activity by using agonists, thrombin, ADP, collagen, or arachidonic acid (in vitro and ex vivo), and anticoagulant activity by measuring the clotting parameters: activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen dosage (in vitro and ex vivo). The result of this study reported that the strongest antiaggregant effect of CAE in vitro was observed on the ADP-induced aggregation with inhibitions up to 90 %, while, in ex vivo experiments, the inhibition (more than 80 %) was observed with all agonists. Anticoagulant effect of CAE significantly prolonged the TT and decreased the fibrinogen level in vitro and ex vivo without interfering with APTT and PT. The bleeding time in mice and rats was significantly increased by CAE. The antiplatelet and anticoagulant effect observed in this study suggest that Juglans regia could have antithrombotic and/or thrombolytic activities and provide an alternative therapy against thrombotic complications related to cardiovascular diseases