1 research outputs found
NIR-to-Red Upconversion Nanoparticles with Minimized Heating Effect for Synchronous Multidrug Resistance Tumor Imaging and Therapy
Lanthanide-doped
upconversion nanoparticles (UCNPs), especially the 808 nm activated
UCNPs, are promising imaging agents for biological applications because
of their minimal tissue overheating effects and low autofluorescence
background. Optimizing the emission peaks located in the “biological
window (600–1100 nm)” is of vital importance to obtain
the maximum penetration depth and intense deep tissue imaging. On
the other hand, because of the widely existing multidrug resistance
(MDR) of tumor cells, traditional tumor chemotherapy often fails to
achieve the desired effect. Herein, a new type of 808 nm excited pure
red luminescence core–shell Nd<sup>3+</sup>-sensitized NaYÂ(Mn)ÂF<sub>4</sub>:Yb/Er@NaYbF<sub>4</sub>:Nd UCNPs (CSUCNPs) was designed and
synthesized for deep tissue imaging and MDR tumor diagnosis with a
minimized heating effect. In the meanwhile, d-α-tocopherol
polyethylene glycol 1000 succinate (TPGS) coating was introduced to
endow CSUCNPs with capabilities of drug loading and overcoming MDR.
The in vitro cytotoxicity test revealed that CSUCNPs-TPGS-doxorubicin
(D-CSUCT) had excellent MDR cancer cell killing efficacy. The in vivo
test showed that D-CSUCT can target the tumor site by enhanced retention
effect, and the intense luminescent signals from the tumor site in
the deep tissue were detected. Generally, this work shows D-CSUCT
can overcome the MDR effect, diagnose the tumor, inhibit tumor growth,
and induce tumor cells necrosis and apoptosis, without causing damage
to major organs and other side effects. Overall, the study demonstrates
the conjugation of red-emitted UCNPs with a minimized heating effect
and that the anti-MDR carrier is highly promising for developing multifunctional
theranostic system with effective simultaneous diagnosis and for multidrug-resistant
tumor treatment