Genetic polymorphisms of 17 X-STR loci in two Tunisian populations from Sousse and Makthar

Tunisia has a complex demographic history of migrations from within Africa, Europe, and the Middle East. However, only one population study based on X-STR markers has been reported so far. To investigate the genetic polymorphisms of 17 X-STRs in two Tunisian populations from the cities of Sousse and Makthar, and to reveal the genetic relationships with other reference populations. A total of 194 unrelated healthy individuals were analysed for 17 X-STR markers. Our results indicate that DXS6809 is the most polymorphic locus, whereas DXS6807 is the least informative marker in the populations of Sousse and Makthar. In addition, forensic statistical parameters, such as the power of discrimination in males and females, as well as the mean of exclusion in duos and trios, reveal that the panel of 17 X-STRs is highly informative and useful in different forensic applications. Overall, pairwise genetic distances (Fst) and non-metric MDS plots demonstrate clustering of different populations according to their geographic locations and their historical relationships. Overall, the study of X-STR markers of the Tunisian populations can help to promote the establishment of a forensic DNA reference database in Tunisia and provide reference for future anthropological research.</p

Association between combined genotype of IL23R/IL17A and IL17F polymorphisms and CRC treatments.

<p>Association between combined genotype of IL23R/IL17A and IL17F polymorphisms and CRC treatments.</p

IL17F genotypes impact on overall survival stratified by surgery.

<p>(A) palliative surgery and (B) radical surgery; in CRC patients according to IL17F genotype (IL17F AA vs. IL17F AGGG). P-values from the log-rank test are indicated. OS: overall survival.</p

IL17F genotypes impact on overall survival stratified by neoadjuvant chemotherapy.

<p>(A) withoutneoadjuvant chemotherapy (<b>p = 0,003</b>) and (B) with neoadjuvant chemotherapy (<b>p = 0,026</b>); in CRC patients according to IL17F genotype (IL17F AA vs. IL17F AGGG). P-values from the log-rank test are indicated. OS: overall survival.</p

IL17F genotypes impact on overall survival stratified by chemotherapy.

<p>(A) Without chemotherapy and (B) with chemotherapy; in CRC patients according to IL17F genotype (IL17F AA vs. IL17F AGGG). P-values from the log-rank test are indicated. OS: overall survival.</p

Characteristics of study subjects.

<p>Characteristics of study subjects.</p

Association between IL17A, IL17F and IL23R polymorphisms and CRC treatments.

<p>*Relative risk (RR) = Event rate (treatment)/Event rate (Placebo).</p><p>**Relative risk reduction (RRR) = 1- relative risk x 100.</p><p>Association between IL17A, IL17F and IL23R polymorphisms and CRC treatments.</p